ALOX15 (P16050) - Overview - Molecular Target Synopsis
ALOX15, Arachidonate 15-lipoxygenase
Enzyme Classification 18.104.22.168
Also Known as LOX15_HUMAN, ALOX15, LOG15
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass. Interacts with PEBP1; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|662||ENSG00000161905||ENST00000570836, ENST00000293761||ENSP00000458832, ENSP00000293761||P16050-1|
UniProt: ALOX15 is active in the following subcellular-locations: cell membrane, cytoplasm, cytosol, lipid droplet.
GO terms: ALOX15 is active in the following subcellular-locations: cytosol, extrinsic component of cytoplasmic side of plasma membrane, lipid droplet, membrane, plasma membrane.