Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

POL30 (P15873) - Overview - Molecular Target Synopsis

Protein


POL30, Proliferating cell nuclear antigen
UniProt P15873

Also Known as PCNA_YEAST, POL30

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair. Homotrimer (PubMed:15201901). Interacts with RAD30 (PubMed:11545742). Interacts with MCM10 (PubMed:16782870). Interacts with UBP10 (PubMed:22829782).

6E49
PIF1 PEPTIDE BOUND TO PCNA TRIMER
RCSB/PDB
Inspect Structure
See all 3D Structures for POL30

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
258P15873-1

Sub-cellular localization


UniProt: POL30 is active in the following subcellular-locations: nucleus.
GO terms: POL30 is active in the following subcellular-locations: chromosome, nucleus, PCNA complex, replication fork.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project POL30 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For POL30 there are:
27 structures (41 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


POL30 has been screened with compounds ( bioactivities). (see details)