Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACPP (P15309) - Overview - Molecular Target Synopsis

Protein


ACPP, Prostatic acid phosphatase
Enzyme Classification 3.1.3.2
UniProt P15309

Also Known as PPAP_HUMAN, ACPP

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma., Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. Homodimer; dimer formation is required for phosphatase activity.

2MG0
9 RESIDUE FRAGMENT OF
PEPTIDE FROM PROSTATIC ACID PHOSPHATASE
IN THE STRUCTURE OF
PAP262-270 IN SDS MICELLES
RCSB/PDB
Inspect Structure
See all 3D Structures for ACPP

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACPP is active in the following subcellular-locations: cell membrane, lysosome membrane, secreted.
GO terms: ACPP is active in the following subcellular-locations: azurophil granule membrane, extracellular exosome, extracellular space, filopodium, integral component of membrane, intracellular, lysosomal membrane, nucleus, plasma membrane, vesicle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACPP has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, UACC_62, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SR-786, SR, LNCAP

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, HMEC

(see details)

3D Structures


For ACPP there are:
9 structures (21 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACPP has been screened with 51 compounds (69 bioactivities), 6 compounds have bioactivities that show binding affinity of <= 500nM (10 bioactivities). (see details)