Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAC2 (P15153) - Overview - Molecular Target Synopsis


RAC2, Ras-related C3 botulinum toxin substrate 2
UniProt P15153

Also Known as RAC2_HUMAN, RAC2

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. Interacts with DOCK2, which may activate it. Interacts with S100A8 and calprotectin (S100A8/9) (PubMed:10559471, PubMed:15642721). Found in a complex with SH3RF1, MAP3K7/TAK1, MAP2K7/MKK7, MAPK8IP1/JIP1, MAPK8/JNK1 and MAPK9/JNK2.

Inspect Structure
See all 3D Structures for RAC2

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: RAC2 is active in the following subcellular-locations: cytoplasm.
GO terms: RAC2 is active in the following subcellular-locations: cell projection, cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, focal adhesion, lamellipodium, nuclear envelope, phagocytic vesicle membrane, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAC2 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SR, HL_60, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-LY-3, CCRF-SB, UKE-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, HUVEC, NHEK

(see details)

3D Structures

For RAC2 there are:
4 structures (8 chains) solved
4 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RAC2 has been screened with 1 compounds (1 bioactivities). (see details)