Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CYP11B1 (P15150) - Overview - Molecular Target Synopsis

Protein


CYP11B1, Cytochrome P450 11B1, mitochondrial
Enzyme Classification 1.14.15.4
UniProt P15150

Also Known as C11B1_BOVIN, CYP11B1

Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
503P15150-1

Sub-cellular localization


UniProt: CYP11B1 is active in the following subcellular-locations: mitochondrion membrane.
GO terms: CYP11B1 is active in the following subcellular-locations: mitochondrial inner membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CYP11B1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry


CYP11B1 has been screened with 46 compounds (71 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)