Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FABP4 (P15090) - Overview - Molecular Target Synopsis

Protein


FABP4, Fatty acid-binding protein, adipocyte
UniProt P15090

Also Known as FABP4_HUMAN, FABP4

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Monomer (PubMed:15357969, PubMed:17077479). Homodimer. Interacts with PPARG.

6AYL
HUMAN ADIPOCYTE LIPID-BINDING PROTEIN FABP4 IN COMPLEX WITH FLUORESCEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for FABP4

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
132ENSG00000170323ENST00000256104ENSP00000256104P15090-1
39ENSG00000170323ENST00000522659ENSP00000428385

Sub-cellular localization


UniProt: FABP4 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: FABP4 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome, lipid droplet, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FABP4 has gain in 18 cell-lines, loss in 2 cell-lines and no signal in 985 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_5, PC_3, 786_0

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Calu-6, UM-UC-1, SW 780

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, SK-N-SH, HSMM

(see details)

3D Structures


For FABP4 there are:
31 structures (31 chains) solved
28 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

FABP4 is solved in complex with the approved drug(s):

IBP/DEXIBUPROFEN (3P6H_A),
FLU/FLUORESCEIN (6AYL_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FABP4 has been screened with 247 compounds (391 bioactivities), 53 compounds have bioactivities that show binding affinity of <= 500nM (69 bioactivities). (see details)