Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

murD (P14900) - Overview - Molecular Target Synopsis

Protein


murD, UDP-N-acetylmuramoylalanine--D-glutamate ligase
Enzyme Classification 6.3.2.9
UniProt P14900

Also Known as MURD_ECOLI, murD

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).

5A5E
CRYSTAL STRUCTURE OF MURD LIGASE FROM ESCHERICHIA COLI
RCSB/PDB
Inspect Structure
See all 3D Structures for murD

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
438P14900-1

Sub-cellular localization


UniProt: murD is active in the following subcellular-locations: cytoplasm.
GO terms: murD is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project murD has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For murD there are:
22 structures (22 chains) solved
20 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


murD has been screened with 108 compounds (129 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)