Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MMP9 (P14780) - Overview - Molecular Target Synopsis

Protein


MMP9, Matrix metalloproteinase-9
Enzyme Classification 3.4.24.35
UniProt P14780

Also Known as MMP9_HUMAN, MMP9, CLG4B

May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Exists as monomer or homodimer; disulfide-linked (PubMed:1281792, PubMed:7683678). Exists also as heterodimer with LCN2 (PubMed:1281792, PubMed:7683678). Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1 (PubMed:16512877).

6ESM
CRYSTAL STRUCTURE OF MMP9 IN COMPLEX WITH INHIBITOR BE4.
RCSB/PDB
Inspect Structure
See all 3D Structures for MMP9

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
707ENSG00000100985ENST00000372330ENSP00000361405P14780-1

Sub-cellular localization


UniProt: MMP9 is active in the following subcellular-locations: extracellular matrix, extracellular space, secreted.
GO terms: MMP9 is active in the following subcellular-locations: collagen-containing extracellular matrix, extracellular exosome, extracellular region, extracellular space, ficolin-1-rich granule lumen, tertiary granule lumen.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MMP9 has gain in 9 cell-lines, loss in 0 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: LOXIMVI, OVCAR_8, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVCAR433, SCC-25, HN

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For MMP9 there are:
25 structures (51 chains) solved
20 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MMP9 has been screened with 4532 compounds (6303 bioactivities), 1732 compounds have bioactivities that show binding affinity of <= 500nM (2197 bioactivities). (see details)