Molecular Target Synopsis
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NMT1 (P14743) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed22
Chains with at least one site assessed as druggable using the strict criteria22
Chains with at least one site assessed as druggable using the relaxed criteria22


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2P6G_B Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 75.3 56 Yes Yes
2 empty 2.47 68.9 37.4 No No
3 empty 1.69 70.2 20.9 No No
4 empty 2.56 63.9 31.5 No No
5 empty 2.2 73.8 21.6 No No
6 empty 2.32 64.8 20 No No
7 empty 1.98 68.6 23.3 No No
8 empty 2.65 69.3 21.6 No No
9 empty 2.24 63.6 27.6 No No
10 empty 2.03 64.6 21.9 No No
2P6F_E Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 77.6 43.5 Yes Yes
2 empty 2.47 69.7 31.2 No No
3 empty 1.83 67.6 25.6 No No
4 empty 2.08 71.1 21.5 No No
5 empty 2.57 67.2 23.3 No No
6 empty 1.92 68.9 17.1 No No
7 empty 2.54 69.3 20.8 No No
8 empty 2.39 61.6 18 No No
9 empty 2.18 67.2 18.6 No No
10 empty 2.22 65.2 18.1 No No
2P6F_F Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.5 76.9 51.5 Yes Yes
2 empty 2.33 69.6 40.8 No No
3 empty 1.61 65.9 44.9 No No
4 empty 2.1 67.1 31.3 No No
5 empty 2.17 75.8 19.6 No No
6 empty 2.37 69.9 17 No No
7 empty 2.41 61.9 13.9 No No
8 empty 2.45 65.9 19.9 No No
9 empty 2.07 66.3 16.4 No No
10 empty 1.91 78.3 12 No No
2P6E_A Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 79.8 49.5 Yes Yes
2 empty 2.36 68.6 40.8 No No
3 empty 1.53 66.8 30.2 No No
4 empty 2.14 70.5 26.6 No No
5 empty 2.22 70.5 21.1 No No
6 empty 2.34 58.8 24.5 No No
7 empty 2.35 67.1 24.9 No No
8 empty 1.91 67.3 21.8 No No
9 empty 2.04 69.6 17.7 No No
10 empty 2.26 56.4 18.5 No No
1IIC_A Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 72.6 58.2 Yes Yes
2 empty 2.14 67.5 29.7 No No
3 empty 2.18 71.1 18.6 No No
4 empty 2.2 72.8 26.4 No No
5 empty 1.98 72.3 23.2 No No
6 empty 2.14 66.2 23.1 No No
7 empty 2.3 57.9 21 No No
8 empty 2.51 63.8 14.2 No No
9 empty 1.99 63.1 19.7 No No
10 empty 2.17 59.9 12.8 No No
2P6G_C Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 74.7 50.8 Yes Yes
2 empty 2.25 74.1 22.6 No No
3 empty 2.1 68.9 28.5 No No
4 empty 1.59 68.7 22.1 No No
5 empty 2.24 66.4 24.9 No No
6 empty 2.19 74.3 20.9 No No
7 empty 2.34 69.5 25.3 No No
8 empty 2.31 63 20.2 No No
9 empty 2.47 67.2 18.8 No No
10 empty 1.75 64.7 18.2 No No
2P6G_E Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 74.2 47.8 Yes Yes
2 empty 2.36 69.1 42.1 No No
3 empty 1.74 69.5 40.8 No No
4 empty 2.24 73.5 24.8 No No
5 empty 2.36 68.1 20.7 No No
6 empty 2.39 63.5 22.2 No No
7 empty 1.95 69.4 18.1 No No
8 empty 1.9 69.1 15.6 No No
9 empty 2.26 63.2 18.4 No No
10 empty 2.45 74.8 15.2 No No
2P6G_F Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 74.6 49.6 Yes Yes
2 empty 2.24 68.9 26.8 No No
3 empty 1.88 65.1 23.9 No No
4 empty 2.06 71.3 27.2 No No
5 empty 2.14 72.4 20.9 No No
6 empty 2.2 62.4 24.6 No No
7 empty 2.29 61.5 23.5 No No
8 empty 2.59 61.3 16.9 No No
9 empty 2.35 65.6 18.8 No No
10 empty 2.14 68.1 19.3 No No
1IIC_B Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 72.5 53.8 Yes Yes
2 empty 2.02 69.1 21.9 No No
3 empty 2.07 69.1 26.1 No No
4 empty 2.07 69.4 28.5 No No
5 empty 2.25 60.8 22 No No
6 empty 1.98 68.1 27.1 No No
7 empty 2.05 71.9 17.9 No No
8 empty 1.82 61.2 11.6 No No
9 empty 2.18 71.3 10.9 No No
10 empty 1.67 98.9 0 Yes No
2P6F_C Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.45 72.7 50.4 Yes Yes
2 empty 2.55 70 42.4 No No
3 empty 1.95 66.3 26.6 No No
4 empty 2.15 72.3 21.4 No No
5 empty 2.18 66.1 24.9 No No
6 empty 2.03 65.5 16.2 No No
7 empty 2.21 63.6 15 No No
8 empty 2.32 68.6 19.2 No No
9 empty 2.32 69.5 26.4 No No
10 empty 1.68 67 18.1 No No
2P6E_F Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 75.9 49.6 Yes Yes
2 empty 2.43 70.9 40.6 No No
3 empty 1.93 63.9 43.6 No No
4 empty 2.09 66.7 33.6 No No
5 empty 2.16 72.7 20.6 No No
6 empty 2.52 69.3 17.6 No No
7 empty 2.54 66 22.2 No No
8 empty 2.57 60.9 21.6 No No
9 empty 2.01 65.6 17.6 No No
10 empty 2.11 64.1 11.8 No No
2P6E_C Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 77.7 44.6 Yes Yes
2 empty 2.42 71.2 42.1 No No
3 empty 1.92 65.9 27.2 No No
4 empty 2.11 69.8 31.6 No No
5 empty 2 70.6 21.1 No No
6 empty 2.26 69.9 20.9 No No
7 empty 2.22 68.7 19 No No
8 empty 1.94 75.5 18.1 No No
9 empty 2.26 69.8 11.6 No No
10 empty 2.11 70.6 17.5 No No
2P6F_B Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.44 75.3 55.3 Yes Yes
2 empty 2.21 66.3 43 No No
3 empty 1.72 68.9 36.2 No No
4 empty 2.23 71.7 19.4 No No
5 empty 2.02 70.6 16.7 No No
6 empty 2.37 66.9 21.4 No No
7 empty 2.38 64.3 20.3 No No
8 empty 2.2 69 19.9 No No
9 empty 2.34 66.1 18.6 No No
10 empty 2.07 71.7 16 No No
2P6E_D Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 77.5 53.5 Yes Yes
2 empty 2.23 66.5 40.9 No No
3 empty 2.16 67.9 36.4 No No
4 empty 1.81 66.9 26.4 No No
5 empty 2.23 73.3 21 No No
6 empty 2.07 69.7 25.1 No No
7 empty 2.41 64.9 17.9 No No
8 empty 2.48 71.3 18 No No
9 empty 2.25 84.2 11.8 No No
10 empty 2.02 69.3 19.4 No No
2P6F_A Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 74.3 55.8 Yes Yes
2 empty 2.35 68 41.4 No No
3 empty 1.54 66 36.4 No No
4 empty 2.14 70.6 30.1 No No
5 empty 2.24 70.8 31.1 No No
6 empty 2.48 61 22.9 No No
7 empty 2.55 64.8 19 No No
8 empty 1.87 65.2 21.3 No No
9 empty 2.1 66.3 17.6 No No
10 empty 1.74 68.5 16.3 No No
1IID_A Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 72.4 58.5 Yes Yes
2 empty 2.19 68.5 27.8 No No
3 empty 2.09 68.1 21.4 No No
4 empty 1.99 70 26.4 No No
5 empty 1.97 70.9 18.5 No No
6 empty 2.07 61.2 12.8 No No
7 empty 1.89 55.4 13.9 No No
8 empty 1.56 71.2 16.8 No No
9 empty 2.18 76 9.2 No No
10 empty 2.14 67.5 11.7 No No
2P6E_B Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 81.2 54 Yes Yes
2 empty 2.14 68.4 45.5 No No
3 empty 1.85 72.1 39.7 No No
4 empty 2.14 67.7 28.5 No No
5 empty 2.61 65.8 27.6 No No
6 empty 2.39 63.4 20.3 No No
7 empty 2.14 68.5 19.7 No No
8 empty 1.88 76.3 10.6 No No
9 empty 1.69 98.9 0 Yes No
10 empty 1.4 72.1 13.9 No No
2NMT_A Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 71.6 48.4 Yes Yes
2 empty 2.06 69.5 24.3 No No
3 empty 1.99 58.6 23 No No
4 bound 2.02 65.5 20 No No
5 empty 2.1 66.3 17.7 No No
6 empty 1.73 71.1 13.2 No No
7 empty 1.84 53.9 17.3 No No
8 empty 1.83 69.1 15.1 No No
9 empty 1.78 53.9 14.2 No No
10 bound 1.92 61.4 11.2 No No
2P6G_D Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 79.1 45.3 Yes Yes
2 empty 2.5 68.2 41.6 No No
3 empty 1.79 68.6 26 No No
4 empty 2.25 69.4 24.1 No No
5 empty 2.04 66.8 25.6 No No
6 empty 2.5 65.1 22.1 No No
7 empty 2.1 62.5 21.4 No No
8 empty 1.97 64.2 22.6 No No
9 empty 1.95 61.1 22.5 No No
10 empty 2.42 64.1 19.9 No No
2P6E_E Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 79.3 42.3 Yes Yes
2 empty 2.39 70.1 33.6 No No
3 empty 1.84 66.3 30.3 No No
4 empty 2.07 70.8 20.5 No No
5 empty 1.92 69.9 19 No No
6 empty 2.46 67.9 20.8 No No
7 empty 2.32 64.4 20.8 No No
8 empty 2.32 64.4 16.9 No No
9 empty 2.18 66.1 16 No No
10 empty 2.1 71 16.1 No No
2P6G_A Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 72.8 55 Yes Yes
2 empty 2.08 66.1 37.3 No No
3 empty 2.43 69.9 36.7 No No
4 empty 1.85 69.6 26.1 No No
5 empty 2.12 72.1 18.8 No No
6 empty 2.23 65.4 21.4 No No
7 empty 2.17 59.5 22 No No
8 empty 1.79 64.2 18.9 No No
9 empty 2.35 62 19.8 No No
10 empty 2.09 62.2 20.7 No No
2P6F_D Glycylpeptide N-tetradecanoyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 76.8 44.2 Yes Yes
2 empty 2.23 67.9 32.3 No No
3 empty 1.94 69.5 24.9 No No
4 empty 2.08 70.4 21.7 No No
5 empty 1.99 67.1 19.5 No No
6 empty 2.51 69.6 17.9 No No
7 empty 2.32 70.6 19.5 No No
8 empty 2.28 63 18.7 No No
9 empty 2.09 71.9 18.9 No No
10 empty 1.73 67.5 17.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed14
Domains assessed as druggable using the strict criteria11
Domains assessed as druggable using the relaxed criteria14

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1IIC_B (62425) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-myristoyl transferase NMT 2.2Å Yes No
1IIC_B (62424) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-myristoyl transferase NMT 2.2Å Yes Yes
1IIC_A (62422) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-myristoyl transferase NMT 2.2Å Yes Yes
1IIC_A (62423) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-myristoyl transferase NMT 2.2Å Yes No
1IID_A (62426) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-myristoyl transferase NMT 2.5Å Yes Yes
1IID_A (62427) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-myristoyl transferase NMT 2.5Å Yes Yes
2NMT_A (40821) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-myristoyl transferase NMT 2.9Å Yes Yes
2NMT_A (40822) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-myristoyl transferase NMT 2.9Å Yes No
2P6E_A (3170502) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), UNMATCHED 2.9Å Yes Yes
2P6E_A (3170503) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-myristoyl transferase NMT 2.9Å Yes Yes
2P6F_A (3170506) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-myristoyl transferase NMT 3.1Å Yes Yes
2P6F_A (3170505) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), UNMATCHED 3.1Å Yes Yes
2P6G_A (3170509) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-myristoyl transferase NMT 3Å Yes Yes
2P6G_A (3170508) Glycylpeptide N-tetradecanoyltransferase Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), UNMATCHED 3Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score