Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC2A4 (P14672) - Overview - Molecular Target Synopsis

Protein


SLC2A4, Solute carrier family 2, facilitated glucose transporter member 4
UniProt P14672

Also Known as GLUT4_HUMAN, SLC2A4, GLUT4

Insulin-regulated facilitative glucose transporter. Interacts with NDUFA9 (By similarity). Binds to DAXX (PubMed:11842083). Interacts via its N-terminus with SRFBP1 (PubMed:16647043). Interacts with TRARG1; the interaction is required for proper SLC2A4 reacycling after insulin stimulation.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC2A4 has gain in 1 cell-lines, loss in 5 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, MCF7, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to SLC2A4 there are:
8 structures (10 chains) solved
8 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC2A4 is solved in complex with the approved drug(s):

BGC/DEXTROSE (4ZW9_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC2A4 has been screened with 11 compounds (11 bioactivities). (see details)