Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC2A4 (P14672) - Overview - Molecular Target Synopsis


SLC2A4, Solute carrier family 2, facilitated glucose transporter member 4
UniProt P14672

Also Known as GLUT4_HUMAN, SLC2A4, GLUT4

Insulin-regulated facilitative glucose transporter. Interacts with NDUFA9 (By similarity). Binds to DAXX (PubMed:11842083). Interacts via its N-terminus with SRFBP1 (PubMed:16647043). Interacts with TRARG1; the interaction is required for proper SLC2A4 reacycling after insulin stimulation.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC2A4 has gain in 1 cell-lines, loss in 5 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_OV_3, MCF7, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 50% identity similarity to SLC2A4 there are:
8 structures (10 chains) solved
8 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC2A4 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

SLC2A4 has been screened with 11 compounds (11 bioactivities). (see details)