Molecular Target Synopsis
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INSRR (P14616) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
(view alignment) INSR (P06213) INS (P01308) 3W12_E 55.52 6.0E-96 NAG BMA MAN
(view alignment) INSR (P06213) - 2HR7_A 54.04 0 P33 NAG BMA MAN FUC
(view alignment) ALK (Q9UM73) - 4Z55_A 43.46 7.0E-69 4LO
(view alignment) ALK (Q9UM73) - 4CLI_A 44.07 2.0E-67 5P8
(view alignment) NTRK3 (Q16288) - 3V5Q_B 43.68 2.0E-60 0F4
(view alignment) NTRK1 (P04629) - 4F0I_A 43.73 2.0E-61 -
(view alignment) ALK (Q9UM73) - 2XB7_A 43.88 9.0E-67 GUI
(view alignment) ALK (Q9UM73) - 6EBW_A 44.07 1.0E-67 -
(view alignment) ALK (Q9UM73) - 5AAC_A 44.07 3.0E-67 VGH
(view alignment) FGFR1 (P11362) - 5A46_A 37.03 7.0E-56 38O
(view alignment) RET (P07949) - 5FM3_A 40.14 2.0E-57 PP1
(view alignment) ALK (Q9UM73) - 4CNH_B 44.07 2.0E-67 3U9
(view alignment) ALK (Q9UM73) - 4FNZ_A 43.42 9.0E-69 NZF
(view alignment) IGF1R (P08069) - 5HZN_A 76.97 0 66A MES
(view alignment) ALK (Q9UM73) - 5A9U_A 44.07 3.0E-67 5P8
(view alignment) FGFR1 (P11362) - 5A4C_A 38.64 3.0E-56 XOJ
(view alignment) NTRK1 (P04629) - 6D22_A 43.73 2.0E-61 -
(view alignment) ALK (Q9UM73) - 4FNW_A 43.09 4.0E-68 -
(view alignment) IGF1R (P08069) - 3F5P_L 77.78 0 741
(view alignment) ALK (Q9UM73) - 6CDT_A 44.07 2.0E-67 -
(view alignment) ALK (Q9UM73) - 2YHV_A 43.69 2.0E-68 -
(view alignment) ALK (Q9UM73) - 5FTO_A 43.88 9.0E-67 YMX
(view alignment) ROS1 (P08922) - 4UXL_A 46.6 3.0E-65 5P8
(view alignment) IGF1R (P08069) - 5FXR_A 77.85 0 8LN
(view alignment) RET (P07949) - 4CKJ_A 40.14 4.0E-57 ADN
(view alignment) INSR (P06213) - 3EKK_A 74.26 2.0E-130 GS2
(view alignment) NTRK1 (P04629) - 4AOJ_B 42.91 3.0E-63 V4Z
(view alignment) IGF1R (P08069) - 3F5P_M 77.78 0 741
(view alignment) INSR (P06213) Irs2 (P81122) 3BU6_A 74.59 0 -
(view alignment) IGF1R (P08069) - 5U8R_A 51.84 0 NAG MLT
(view alignment) IGF1R (P08069) - 3F5P_G 77.78 0 741
(view alignment) FGFR1 (P11362) - 5O4A_A 39.08 9.0E-56 9K8
(view alignment) IGF1R (P08069) - 3QQU_A 77.93 0 01P
(view alignment) FGFR1 (P11362) - 4RWI_A 39.44 3.0E-56 -
(view alignment) IGF1R (P08069) - 3F5P_B 77.78 0 741
(view alignment) IGF1R (P08069) - 3F5P_E 77.78 0 741
(view alignment) ALK (Q9UM73) - 4FOB_A 43.46 7.0E-69 0US
(view alignment) ALK (Q9UM73) - 4DCE_A 43.46 5.0E-69 0JF
(view alignment) IGF1R (P08069) - 1M7N_B 78.27 0 -
(view alignment) GCN4 (P03069), INSR (P06213) INS (P01308) 6HN5_E 49.94 0 NAG
(view alignment) IGF1R (P08069) - 1JQH_C 77.78 0 ANP
(view alignment) IGF1R (P08069) - 3LW0_B 76.97 0 CCX
(view alignment) NTRK1 (P04629) - 5KMO_A 42.91 4.0E-63 6UM
(view alignment) IGF1R (P08069) IRS1 (P35568) 1K3A_A 77.93 0 ACP
(view alignment) NTRK3 (Q16288) - 4YMJ_B 43.68 2.0E-60 4EJ
(view alignment) INSR (P06213) INS (P01308) 3W13_E 55.52 6.0E-96 NAG BMA MAN
(view alignment) FGFR1 (P11362) - 3RHX_A 39.08 8.0E-56 3RH
(view alignment) NTRK1 (P04629) - 5KMJ_A 42.91 4.0E-63 6UF
(view alignment) INSR (P06213) INS (P01318), INS (P01308) 6CEB_A 49.67 0 NAG BMA FUC
(view alignment) IGF1R (P08069) - 3NW5_A 77.7 0 LGX
(view alignment) ALK (Q9UM73) - 4FOC_A 43.46 7.0E-69 0UU
(view alignment) IGF1R (P08069) - 2OJ9_A 77.7 0 BMI
(view alignment) ALK (Q9UM73) - 4ANS_A 43.37 8.0E-68 VGH
(view alignment) RET (P07949) - 2X2M_B 40.14 4.0E-57 X2M
(view alignment) INSR (P06213) - 5HHW_A 74.26 0 60O
(view alignment) INSR (P06213) Irs2 (P81122) 3BU3_A 74.59 0 -
(view alignment) INSR (P06213) - 3EKN_A 74.26 2.0E-130 GS3
(view alignment) ALK (Q9UM73) - 4CMU_A 44.07 2.0E-67 IV7
(view alignment) NTRK1 (P04629) - 5JFV_A 43.73 2.0E-61 6K1
(view alignment) ALK (Q9UM73) - 3LCT_A 43.46 7.0E-69 ADP
(view alignment) ALK (Q9UM73) - 5AAA_A 43.73 4.0E-67 VGH
(view alignment) ALK (Q9UM73) - 4CCU_A 44.07 2.0E-67 AWF
(view alignment) IGF1R (P08069) - 3F5P_R 77.78 0 741
(view alignment) INSR (P06213) - 2HR7_B 54.04 0 NAG BMA MAN FUC
(view alignment) IGF1R (P08069) - 5HZN_G 76.97 0 66A MES
(view alignment) ALK (Q9UM73) - 4MKC_A 43.46 7.0E-69 4MK
(view alignment) NTRK2 (Q16620) - 4ASZ_A 42.71 2.0E-62 -
(view alignment) ALK (Q9UM73) - 4JOA_A 43.46 7.0E-69 3DK
(view alignment) NTRK1 (P04629) - 6DKW_A 43.73 2.0E-61 GXA
(view alignment) RET (P07949) - 2IVS_A 40.14 4.0E-57 ACK
(view alignment) INSR (P06213) INS (P01308) 3W11_E 55.52 6.0E-96 NAG BMA MAN
(view alignment) NTRK1 (P04629) - 6DKB_A 42.91 3.0E-63 FKY
(view alignment) GCN4 (P03069), INSR (P06213) INS (P01308) 6HN5_F 49.94 0 NAG
(view alignment) INSR (P06213) - 1GAG_A 74.26 0 -
(view alignment) IGF1R (P08069) - 1M7N_A 78.27 0 -
(view alignment) FGFR1 (P11362) - 5FLF_B 39.44 1.0E-56 -
(view alignment) RET (P07949) - 2IVV_A 39.8 2.0E-56 PP1
(view alignment) FGFR1 (P11362) - 5FLF_D 39.44 1.0E-56 PGE
(view alignment) ALK (Q9UM73) - 5FTQ_A 43.88 9.0E-67 U4W
(view alignment) NTRK1 (P04629) - 5KMI_A 42.91 4.0E-63 6UE
(view alignment) IGF1R (P08069) - 5HZN_H 76.97 0 66A MES
(view alignment) INSR (P06213) - 5J3H_E 55.52 5.0E-96 NAG BMA FUC MAN
(view alignment) ALK (Q9UM73) - 4CLJ_A 44.41 7.0E-68 5P8
(view alignment) GCN4 (P03069), INSR (P06213) - 6HN4_E 49.94 0 -
(view alignment) NTRK1 (P04629) - 5KVT_A 44.16 3.0E-61 YMX
(view alignment) NTRK1 (P04629) - 4AOJ_C 42.91 3.0E-63 V4Z
(view alignment) INSR (P06213) INS (P01318), INS (P01308) 6CE9_A 49.67 0 NAG BMA FUC
(view alignment) INSR (P06213) INS (P01317) 5KQV_F 52.63 0 NAG FUC
(view alignment) IGF1R (P08069) - 2ZM3_D 77.78 0 575
(view alignment) NTRK1 (P04629) - 4AOJ_A 42.91 3.0E-63 V4Z
(view alignment) RET (P07949) - 4CKI_A 39.8 2.0E-56 ADN
(view alignment) ALK (Q9UM73) - 2YFX_A 44.41 7.0E-68 VGH
(view alignment) IGF1R (P08069) - 1P4O_A 77.64 0 -
(view alignment) ALK (Q9UM73) - 4CCB_A 44.07 2.0E-67 OFG
(view alignment) INSR (P06213) IGF1 (P05019), IGF1R (P08069) 4XSS_E 55.52 5.0E-96 NAG BMA FUC
(view alignment) IGF1R (P08069) - 3LVP_A 74.7 0 EPE PDR
(view alignment) ALK (Q9UM73) - 4CTC_A 44.07 2.0E-67 J99
(view alignment) INSR (P06213) - 1IRK_A 74.26 0 -
(view alignment) IGF1R (P08069) - 2ZM3_A 77.78 0 575
(view alignment) NTRK1 (P04629) - 6D1Z_A 42.91 3.0E-63 FQD FQM
(view alignment) NTRK1 (P04629) - 5KMN_A 42.91 4.0E-63 6UK
(view alignment) INSR (P06213) Irs2 (P81122) 3BU5_A 74.59 0 ATP
(view alignment) IGF1R (P08069) - 1JQH_A 77.78 0 ANP
(view alignment) ALK (Q9UM73) - 5KZ0_A 44.07 2.0E-67 6YL
(view alignment) NTRK1 (P04629) - 4GT5_A 43.73 2.0E-61 -
(view alignment) IGF1R (P08069) - 3F5P_T 77.78 0 741
(view alignment) INSR (P06213) PTPN1 (P18031) 2B4S_D 74.59 0 -
(view alignment) RET (P07949) - 6FEK_A 42.91 1.0E-59 ADN
(view alignment) INSR (P06213) - 5E1S_A 74.26 0 5JA
(view alignment) IGF1R (P08069) - 5HZN_F 76.97 0 66A MES
(view alignment) IGF1R (P08069) - 3F5P_D 77.78 0 741
(view alignment) NTRK1 (P04629) - 4PMT_A 43.73 2.0E-61 31Y
(view alignment) FGFR1 (P11362) - 5AM7_B 39.44 2.0E-56 38O
(view alignment) IGF1R (P08069) - 3F5P_I 77.78 0 741
(view alignment) IGF1R (P08069) - 3LW0_D 76.97 0 CCX
(view alignment) ALK (Q9UM73) - 4CMO_A 44.07 2.0E-67 YPW
(view alignment) IGF1R (P08069) - 3QQU_C 77.93 0 01P
(view alignment) ALK (Q9UM73) - 3LCS_A 43.46 7.0E-69 STU
(view alignment) IGF1R (P08069) - 3NW7_A 77.7 0 LGV
(view alignment) ALK (Q9UM73) - 5IUI_A 43.42 9.0E-69 45Q
(view alignment) FGFR1 (P11362) - 4ZSA_A 39.08 8.0E-56 4UT
(view alignment) RET (P07949) - 5FM2_A 40.14 2.0E-57 PP1
(view alignment) NTRK1 (P04629) - 4PMM_A 43.73 2.0E-61 31V
(view alignment) IGF1R (P08069) - 5FXS_A 77.2 0 OZN
(view alignment) IGF1R (P08069) - 3LVP_D 74.7 0 PDR
(view alignment) INSR (P06213) - 3ETA_A 74.24 1.0E-126 351
(view alignment) NTRK1 (P04629) - 4YPS_A 43.73 2.0E-61 4F6
(view alignment) INSR (P06213) - 1I44_A 73.93 4.0E-130 ACP
(view alignment) ALK (Q9UM73) - 6E0R_A 44.07 1.0E-67 -
(view alignment) ALK (Q9UM73) - 4ANQ_A 43.04 2.0E-67 VGH
(view alignment) NTRK1 (P04629) - 5H3Q_A 42.91 3.0E-63 7HF
(view alignment) IGF1R (P08069) - 3I81_A 77.7 0 EBI
(view alignment) RET (P07949) - 2X2L_A 40.14 4.0E-57 X2L
(view alignment) IGF1R (P08069) - 1JQH_B 77.78 0 ANP
(view alignment) ALK (Q9UM73) - 4TT7_A 43.79 1.0E-66 COM
(view alignment) NTRK3 (Q16288) - 3V5Q_A 43.68 2.0E-60 0F4
(view alignment) NTRK1 (P04629) - 4F0I_B 43.73 2.0E-61 -
(view alignment) INSR (P06213) - 4IBM_A 74.75 2.0E-130 IR1
(view alignment) IGF1R (P08069) - 3LW0_A 76.97 0 CCX
(view alignment) NTRK3 (Q16288) - 4YMJ_A 43.68 2.0E-60 4EJ
(view alignment) FGFR1 (P11362) - 4RWI_B 39.44 3.0E-56 -
(view alignment) RET (P07949) - 2IVU_A 40.14 4.0E-57 ZD6
(view alignment) INSR (P06213) Sh2b2 (Q9Z200) 1RQQ_A 74.59 0 -
(view alignment) NTRK1 (P04629) - 4PMP_A 43.73 2.0E-61 31W
(view alignment) INSR (P06213) INS (P01317) 5KQV_E 52.63 0 NAG FUC
(view alignment) ALK (Q9UM73) - 6MX8_A 43.88 8.0E-67 6GY
(view alignment) FGFR1 (P11362) - 4RWK_A 39.44 3.0E-56 66T
(view alignment) ALK (Q9UM73) - 2XBA_A 43.88 9.0E-67 571
(view alignment) INSR (P06213) INS (P01318), INS (P01308) 6CE7_A 49.24 0 -
(view alignment) ALK (Q9UM73) - 4DCE_B 43.46 5.0E-69 0JF
(view alignment) IGF1R (P08069) - 4D2R_A 77.81 0 DYK
(view alignment) IGF1R (P08069) - 5HZN_D 76.97 0 66A MES
(view alignment) ALK (Q9UM73) - 3L9P_A 43.46 7.0E-69 -
(view alignment) FGFR1 (P11362) - 5A46_B 37.03 7.0E-56 38O
(view alignment) FGFR1 (P11362) - 5FLF_E 39.44 1.0E-56 -
(view alignment) IGF1R (P08069) - 3F5P_K 77.78 0 741
(view alignment) INSR (P06213) - 3ETA_B 74.24 1.0E-126 351
(view alignment) NTRK1 (P04629) - 5KMK_A 42.91 4.0E-63 6UG
(view alignment) ALK (Q9UM73) - 4CNH_A 44.07 2.0E-67 3U9
(view alignment) NTRK1 (P04629) - 4YNE_A 43.73 2.0E-61 4EK
(view alignment) ALK (Q9UM73) - 5IUG_A 43.42 9.0E-69 729
(view alignment) FGFR1 (P11362) - 5A4C_B 38.64 3.0E-56 XOJ
(view alignment) IGF1R (P08069) - 3F5P_H 77.78 0 741
(view alignment) NTRK1 (P04629) - 6DKG_A 42.91 3.0E-63 22L GO7
(view alignment) FGFR1 (P11362) - 5O4A_B 39.08 9.0E-56 9K8
(view alignment) INSR (P06213) - 4IBM_B 74.75 2.0E-130 IR1
(view alignment) ALK (Q9UM73) - 5AA8_A 43.73 6.0E-67 5P8
(view alignment) NTRK1 (P04629) - 6D1Y_A 42.91 3.0E-63 FQJ
(view alignment) NTRK1 (P04629) - 5JFW_A 43.73 2.0E-61 6K2
(view alignment) INSR (P06213) IRS1 (P35568) 2Z8C_A 74.26 0 S91
(view alignment) INSR (P06213) - 1IR3_A 74.26 0 ANP
(view alignment) IGF1R (P08069) - 3F5P_F 77.78 0 741
(view alignment) NTRK2 (Q16620) - 4AT5_A 42.71 2.0E-62 MUJ
(view alignment) INSR (P06213) INS (P01318), INS (P01308) 6CE7_B 49.24 0 -
(view alignment) NTRK2 (Q16620) - 4AT4_A 42.71 2.0E-62 T6E
(view alignment) INSR (P06213) - 1P14_A 74.26 1.0E-130 -
(view alignment) NTRK1 (P04629) - 6DKI_A 42.91 3.0E-63 GOD 22L
(view alignment) INSR (P06213) Insr (P15127) 4XST_E 55.52 5.0E-96 NAG FUC
(view alignment) IGF1R (P08069) - 5HZN_B 76.97 0 66A MES
(view alignment) RET (P07949) - 2X2M_A 40.14 4.0E-57 X2M
(view alignment) NTRK1 (P04629) - 5JFX_A 43.73 2.0E-61 6K4
(view alignment) NTRK1 (P04629) - 5JFS_A 43.73 2.0E-61 6K0
(view alignment) ALK (Q9UM73) - 5IMX_A 44.07 2.0E-67 CZ4
(view alignment) ALK (Q9UM73) - 4CMT_A 44.07 2.0E-67 GWH
(view alignment) NTRK1 (P04629) - 5WR7_A 42.91 3.0E-63 RCH
(view alignment) RET (P07949) - 2IVT_A 40.14 4.0E-57 AMP
(view alignment) ALK (Q9UM73) - 4FNX_A 43.09 3.0E-68 -
(view alignment) NTRK1 (P04629) - 4PMS_A 43.73 2.0E-61 31X
(view alignment) INSR (P06213) INS (P01318), INS (P01308) 6CEB_B 49.67 0 NAG BMA FUC
(view alignment) INSR (P06213) - 4XLV_A 73.75 0 ACP
(view alignment) FGFR1 (P11362) - 5Z0S_A 39.08 8.0E-56 960
(view alignment) INSR (P06213) GRB14 (Q14449) 2AUH_A 74.59 0 -
(view alignment) NTRK1 (P04629) - 5KMM_A 42.91 4.0E-63 6UJ
(view alignment) FGFR1 (P11362) - 3RHX_B 39.08 8.0E-56 3RH
(view alignment) INSR (P06213) PTPN1 (P18031) 2B4S_B 74.59 0 -
(view alignment) IGF1R (P08069) - 3F5P_S 77.78 0 741
(view alignment) IGF1R (P08069) - 2ZM3_B 77.78 0 575
(view alignment) IGF1R (P08069) - 3O23_A 77.38 0 MQY
(view alignment) INSR (P06213) INS (P01318), INS (P01308) 6CE9_B 49.67 0 NAG BMA FUC
(view alignment) ALK (Q9UM73) - 5AAB_A 43.73 6.0E-67 VGH
(view alignment) IGF1R (P08069) - 3LVP_C 74.7 0 PDR
(view alignment) FGFR3 (P22607) - 4K33_A 36.18 6.0E-56 ACP
(view alignment) IGF1R (P08069) - 3NW6_A 77.7 0 LGW
(view alignment) ALK (Q9UM73) - 3AOX_A 43.46 7.0E-69 EMH
(view alignment) IGF1R (P08069) IGF1 (P05019) 5U8Q_A 51.84 0 NAG MAN MLT
(view alignment) ALK (Q9UM73) - 5AA9_A 43.73 4.0E-67 5P8
(view alignment) NTRK2 (Q16620) - 4AT3_A 42.71 2.0E-62 LTI
(view alignment) FGFR1 (P11362) - 5FLF_C 39.44 1.0E-56 PGE
(view alignment) INSR (P06213) INS (P01308) 4OGA_E 55.52 5.0E-96 NAG BMA MAN FUC
(view alignment) INSR (P06213) Sh2b2 (Q9Z200) 1RQQ_B 74.59 0 -
(view alignment) ALK (Q9UM73) - 4CD0_A 43.69 2.0E-68 AWJ
(view alignment) NTRK1 (P04629) - 5KML_A 42.91 4.0E-63 6UH
(view alignment) IGF1R (P08069) - 3D94_A 77.74 0 D94
(view alignment) IGF1R (P08069) - 5FXQ_A 77.85 0 GD5
(view alignment) IGF1R (P08069) - 5HZN_C 76.97 0 66A MES
(view alignment) IGF1R (P08069) - 3LW0_C 76.97 0 CCX
(view alignment) ROS1 (P08922) - 3ZBF_A 46.6 3.0E-65 VGH
(view alignment) IGF1R (P08069) - 3QQU_B 77.93 0 01P
(view alignment) IGF1R (P08069) - 5HZN_E 76.97 0 66A MES
(view alignment) FGFR1 (P11362) - 4RWK_B 39.44 3.0E-56 66T
(view alignment) GCN4 (P03069), INSR (P06213) - 6HN4_F 49.94 0 NAG
(view alignment) ALK (Q9UM73) - 4ANL_A 43.04 2.0E-67 -
(view alignment) FGFR1 (P11362) - 5Z0S_B 39.08 8.0E-56 960
(view alignment) RET (P07949) - 2X2K_A 40.14 4.0E-57 X2K
(view alignment) ALK (Q9UM73) - 2YJR_A 43.04 2.0E-67 -
(view alignment) IGF1R (P08069) - 3F5P_A 77.78 0 741
(view alignment) NTRK1 (P04629) - 6D20_A 42.91 3.0E-63 FQG FQD
(view alignment) IGF1R (P08069) - 1P4O_B 77.64 0 -
(view alignment) Musk (Q62838) - 1LUF_A 42.56 8.0E-64 -
(view alignment) INSR (P06213) - 4ZXB_E 49.94 0 NAG BMA FUC MAN
(view alignment) NTRK1 (P04629) - 6DKW_B 43.73 2.0E-61 GXA
(view alignment) RET (P07949) - 2IVS_B 40.14 4.0E-57 ACK
(view alignment) FGFR1 (P11362) - 5FLF_A 39.44 1.0E-56 -
(view alignment) IGF1R (P08069) - 3LVP_B 74.7 0 PDR
(view alignment) FGFR1 (P11362) - 5AM7_A 39.44 2.0E-56 38O
(view alignment) RET (P07949) - 5AMN_A 42.14 2.0E-59 DTQ
(view alignment) ALK (Q9UM73) - 4FOD_A 43.46 5.0E-69 0UV
(view alignment) ALK (Q9UM73) - 4FNY_A 43.09 3.0E-68 I3K
(view alignment) ALK (Q9UM73) - 5IUH_A 43.42 9.0E-69 34Y
(view alignment) FGFR1 (P11362) - 4ZSA_B 39.08 8.0E-56 4UT
(view alignment) ALK (Q9UM73) - 2YJS_A 43.37 7.0E-68 -
(view alignment) IGF1R (P08069) - 1IGR_A 55.08 0 NAG BMA FUC MAN
(view alignment) ALK (Q9UM73) - 6EDL_A 44.07 1.0E-67 -
(view alignment) NTRK1 (P04629) - 5I8A_A 44.16 3.0E-61 69C
(view alignment) IGF1R (P08069) - 2ZM3_C 77.78 0 575
(view alignment) ALK (Q9UM73) - 4CTB_A 44.07 2.0E-67 KVC
(view alignment) IGF1R (P08069) - 3F5P_J 77.78 0 741
(view alignment) IGF1R (P08069) - 3F5P_C 77.78 0 741
(view alignment) IGF1R (P08069) - 3QQU_D 77.93 0 01P
(view alignment) ALK (Q9UM73) - 2XP2_A 44.07 2.0E-67 VGH