Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
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Ligand Efficiency Plot
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INSRR (P14616) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) - HUMAN 2HR7_A 54.04 0 2.3Å P33 NAG BMA MAN FUC 2006-08-15
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) INS (P01308) HUMAN 3W12_E 55.52 6.0E-96 4.3Å NAG BMA MAN 2013-01-09
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4Z55_A 43.46 7.0E-69 1.55Å 4LO 2016-02-03
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CLI_A 44.07 2.0E-67 1.94Å 5P8 2014-05-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4F0I_A 43.73 2.0E-61 2.3Å - 2012-09-05
Protein tyrosine kinase (99%) (view alignment) NTRK3 (Q16288) - HUMAN 3V5Q_B 43.68 2.0E-60 2.19Å 0F4 2012-02-08
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2XB7_A 43.88 9.0E-67 2.5Å GUI 2010-07-28
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 6EBW_A 44.07 1.0E-67 2.455Å J3Y 2019-05-01
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5AAC_A 44.07 3.0E-67 1.63Å VGH 2016-06-08
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6NSP_A 43.73 2.0E-61 2.31Å L0P 2019-05-22
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 5FM3_A 40.14 2.0E-57 2.95Å PP1 2016-12-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_A 76.97 0 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5A9U_A 44.07 3.0E-67 1.59Å 5P8 2016-06-08
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CNH_B 44.07 2.0E-67 1.84Å 3U9 2014-05-28
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FNZ_A 43.42 9.0E-69 2.6Å NZF 2012-08-29
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FNW_A 43.09 4.0E-68 1.75Å - 2012-08-29
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6D22_A 43.73 2.0E-61 2.458Å - 2018-05-02
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6NSS_A 42.91 5.0E-63 1.97Å L0M 2019-05-22
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_L 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2YHV_A 43.69 2.0E-68 1.89Å - 2011-05-18
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 6CDT_A 44.07 2.0E-67 1.8Å - 2019-02-20
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5FTO_A 43.88 9.0E-67 2.21Å YMX 2016-04-06
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5FXR_A 77.85 0 2.4Å 8LN 2016-10-19
Protein tyrosine kinase (100%) (view alignment) ROS1 (P08922) - HUMAN 4UXL_A 46.6 3.0E-65 2.21Å 5P8 2015-03-11
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 4CKJ_A 40.14 4.0E-57 1.65Å ADN 2014-03-05
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4AOJ_B 42.91 3.0E-63 2.75Å V4Z 2012-08-15
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 3EKK_A 74.26 2.0E-130 2.1Å GS2 2008-12-23
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_M 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Irs2 (P81122) HUMAN 3BU6_A 74.59 0 1.95Å - 2008-02-19
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) IGF1R (P08069) - HUMAN 5U8R_A 51.84 0 3Å NAG MLT 2018-02-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_G 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3QQU_A 77.93 0 2.9Å 01P 2011-04-20
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_B 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_E 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FOB_A 43.46 7.0E-69 1.9Å 0US 2012-07-11
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4DCE_A 43.46 5.0E-69 2.03Å 0JF 2012-02-08
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1JQH_C 77.78 0 2.1Å ANP 2002-04-19
Protein tyrosine kinase (99%) (view alignment) NTRK3 (Q16288) - HUMAN 6KZC_A 41.58 1.0E-57 1.97Å DZC 2019-10-09
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1M7N_B 78.27 0 2.7Å - 2003-01-07
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) GCN4 (P03069), INSR (P06213) INS (P01308) HUMAN, BAKER'S YEAST 6HN5_E 49.94 0 3.2Å NAG 2018-11-21
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMO_A 42.91 4.0E-63 2.67Å 6UM 2016-12-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) IRS1 (P35568) HUMAN 1K3A_A 77.93 0 2.1Å ACP 2001-11-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LW0_B 76.97 0 1.79Å CCX 2010-09-29
Protein tyrosine kinase (99%) (view alignment) NTRK3 (Q16288) - HUMAN 4YMJ_B 43.68 2.0E-60 1.92Å 4EJ 2015-06-03
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) INS (P01308) HUMAN 3W13_E 55.52 6.0E-96 4.3Å NAG BMA MAN 2013-01-09
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMJ_A 42.91 4.0E-63 2.04Å 6UF 2016-12-28
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01318), INS (P01308) HUMAN 6CEB_A 49.67 0 4.7Å NAG BMA FUC 2018-03-14
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3NW5_A 77.7 0 2.14Å LGX 2010-07-28
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FOC_A 43.46 7.0E-69 1.7Å 0UU 2012-07-11
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 2OJ9_A 77.7 0 2Å BMI 2007-05-01
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4ANS_A 43.37 8.0E-68 1.84Å VGH 2013-03-27
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 5HHW_A 74.26 0 1.79Å 60O 2016-04-13
Receptor L domain (100%), Furin-like cysteine rich region (100%), Protein tyrosine kinase (100%) (view alignment) INSR (P06213) (A6XGL2) HUMAN 6PXW_A 53.87 0 3.1Å - 2019-09-04
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2X2M_B 40.14 4.0E-57 2.5Å X2M 2010-02-09
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 3EKN_A 74.26 2.0E-130 2.2Å GS3 2008-12-30
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Irs2 (P81122) HUMAN 3BU3_A 74.59 0 1.65Å - 2008-02-19
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CMU_A 44.07 2.0E-67 1.68Å IV7 2014-05-28
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 3LCT_A 43.46 7.0E-69 1.89Å ADP 2010-08-04
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5JFV_A 43.73 2.0E-61 1.59Å 6K1 2017-03-01
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_R 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5AAA_A 43.73 4.0E-67 1.73Å VGH 2016-06-08
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CCU_A 44.07 2.0E-67 1.97Å AWF 2014-01-29
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) - HUMAN 2HR7_B 54.04 0 2.3Å NAG BMA MAN FUC 2006-08-15
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_G 76.97 0 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) NTRK2 (Q16620) - HUMAN 4ASZ_A 42.71 2.0E-62 1.7Å - 2012-08-22
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4MKC_A 43.46 7.0E-69 2.01Å 4MK 2014-04-09
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4JOA_A 43.46 7.0E-69 2.7Å 3DK 2013-07-17
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKW_A 43.73 2.0E-61 2.91Å GXA 2018-07-11
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2IVS_A 40.14 4.0E-57 2Å ACK 2006-08-14
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) INS (P01308) HUMAN 3W11_E 55.52 6.0E-96 3.9Å NAG BMA MAN 2013-01-09
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKB_A 42.91 3.0E-63 2.68Å FKY 2018-07-11
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) GCN4 (P03069), INSR (P06213) INS (P01308) HUMAN, BAKER'S YEAST 6HN5_F 49.94 0 3.2Å NAG 2018-11-21
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2IVV_A 39.8 2.0E-56 2.25Å PP1 2006-08-14
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6PL2_A 42.91 5.0E-63 2.59Å OOM 2019-09-04
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1M7N_A 78.27 0 2.7Å - 2003-01-07
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 6NEC_C 40.14 4.0E-57 1.87Å XIN 2019-06-05
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_B 39.44 1.0E-56 2.58Å - 2016-03-30
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1GAG_A 74.26 0 2.7Å - 2001-01-17
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_D 39.44 1.0E-56 2.58Å PGE 2016-03-30
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5FTQ_A 43.88 9.0E-67 1.7Å U4W 2016-04-06
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMI_A 42.91 4.0E-63 1.868Å 6UE 2016-12-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_H 76.97 0 2.2Å 66A MES 2016-04-06
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) - HUMAN 5J3H_E 55.52 5.0E-96 3.27Å NAG BMA FUC MAN 2016-06-15
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CLJ_A 44.41 7.0E-68 1.66Å 5P8 2014-05-28
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) GCN4 (P03069), INSR (P06213) - HUMAN, BAKER'S YEAST 6HN4_E 49.94 0 4.2Å - 2018-11-21
Protein tyrosine kinase (99%) (view alignment) NTRK1 (P04629) - HUMAN 5KVT_A 44.16 3.0E-61 2.45Å YMX 2017-12-27
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01318), INS (P01308) HUMAN 6CE9_A 49.67 0 4.3Å NAG BMA FUC 2018-03-14
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4AOJ_C 42.91 3.0E-63 2.75Å V4Z 2012-08-15
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01317) HUMAN 5KQV_F 52.63 0 4.4Å NAG FUC 2017-07-19
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 2ZM3_D 77.78 0 2.27Å 575 2008-06-10
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4AOJ_A 42.91 3.0E-63 2.75Å V4Z 2012-08-15
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 4CKI_A 39.8 2.0E-56 2.11Å ADN 2014-03-05
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1P4O_A 77.64 0 1.5Å - 2003-04-29
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2YFX_A 44.41 7.0E-68 1.57Å VGH 2011-05-04
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CCB_A 44.07 2.0E-67 1.88Å OFG 2014-01-29
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) IGF1 (P05019), IGF1R (P08069) HUMAN 4XSS_E 55.52 5.0E-96 3Å NAG BMA FUC 2015-06-10
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LVP_A 74.7 0 3Å EPE PDR 2010-07-21
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6NPT_A 42.91 4.0E-63 2.19Å KWY 2019-05-22
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CTC_A 44.07 2.0E-67 2.03Å J99 2014-05-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 2ZM3_A 77.78 0 2.27Å 575 2008-06-10
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6D1Z_A 42.91 3.0E-63 1.87Å FQD FQM 2018-05-02
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1IRK_A 74.26 0 2.1Å - 1995-02-27
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Irs2 (P81122) HUMAN 3BU5_A 74.59 0 2.1Å ATP 2008-02-19
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMN_A 42.91 4.0E-63 2.136Å 6UK 2016-12-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1JQH_A 77.78 0 2.1Å ANP 2002-04-19
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5KZ0_A 44.07 2.0E-67 2.16Å 6YL 2016-08-17
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4GT5_A 43.73 2.0E-61 2.398Å - 2012-09-26
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_T 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) PTPN1 (P18031) HUMAN 2B4S_D 74.59 0 2.3Å - 2005-11-15
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_F 76.97 0 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 6FEK_A 42.91 1.0E-59 2.08Å ADN 2018-02-28
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 5E1S_A 74.26 0 2.26Å 5JA 2015-10-14
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_D 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 6NE7_A 39.8 2.0E-56 1.99Å AMP 2019-06-05
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4PMT_A 43.73 2.0E-61 2.1Å 31Y 2014-06-18
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5AM7_B 39.44 2.0E-56 1.957Å 38O 2015-03-18
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_I 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LW0_D 76.97 0 1.79Å CCX 2010-09-29
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3QQU_C 77.93 0 2.9Å 01P 2011-04-20
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 3LCS_A 43.46 7.0E-69 1.9Å STU 2010-08-04
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CMO_A 44.07 2.0E-67 1.84Å YPW 2014-05-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3NW7_A 77.7 0 2.11Å LGV 2010-07-28
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5IUI_A 43.42 9.0E-69 1.88Å 45Q 2016-05-18
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 5FM2_A 40.14 2.0E-57 3.3Å PP1 2016-12-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4PMM_A 43.73 2.0E-61 2Å 31V 2014-06-18
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5FXS_A 77.2 0 1.9Å OZN 2016-10-19
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LVP_D 74.7 0 3Å PDR 2010-07-21
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 3ETA_A 74.24 1.0E-126 2.6Å 351 2009-05-26
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4YPS_A 43.73 2.0E-61 2.1Å 4F6 2015-06-03
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1I44_A 73.93 4.0E-130 2.4Å ACP 2001-03-07
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 6E0R_A 44.07 1.0E-67 2.3Å HKJ 2019-05-01
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4ANQ_A 43.04 2.0E-67 1.76Å VGH 2013-03-27
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5H3Q_A 42.91 3.0E-63 2.1Å 7HF 2017-02-22
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2X2L_A 40.14 4.0E-57 2Å X2L 2010-02-09
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3I81_A 77.7 0 2.08Å EBI 2009-12-22
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1JQH_B 77.78 0 2.1Å ANP 2002-04-19
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4TT7_A 43.79 1.0E-66 2.1Å COM 2015-02-11
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 4IBM_A 74.75 2.0E-130 1.8Å IR1 2013-08-21
Protein tyrosine kinase (99%) (view alignment) NTRK3 (Q16288) - HUMAN 3V5Q_A 43.68 2.0E-60 2.19Å 0F4 2012-02-08
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4F0I_B 43.73 2.0E-61 2.3Å - 2012-09-05
Protein tyrosine kinase (99%) (view alignment) NTRK3 (Q16288) - HUMAN 4YMJ_A 43.68 2.0E-60 1.92Å 4EJ 2015-06-03
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LW0_A 76.97 0 1.79Å CCX 2010-09-29
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2IVU_A 40.14 4.0E-57 2.5Å ZD6 2006-08-10
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Sh2b2 (Q9Z200) HUMAN 1RQQ_A 74.59 0 2.6Å - 2003-12-30
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4PMP_A 43.73 2.0E-61 1.8Å 31W 2014-06-18
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01317) HUMAN 5KQV_E 52.63 0 4.4Å NAG FUC 2017-07-19
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 6MX8_A 43.88 8.0E-67 1.96Å 6GY 2018-12-12
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2XBA_A 43.88 9.0E-67 1.95Å 571 2010-07-28
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01318), INS (P01308) HUMAN 6CE7_A 49.24 0 7.4Å - 2018-03-14
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4DCE_B 43.46 5.0E-69 2.03Å 0JF 2012-02-08
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 4D2R_A 77.81 0 2.1Å DYK 2015-04-22
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_D 76.97 0 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 3L9P_A 43.46 7.0E-69 1.8Å - 2010-07-28
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_E 39.44 1.0E-56 2.58Å - 2016-03-30
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_K 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 3ETA_B 74.24 1.0E-126 2.6Å 351 2009-05-26
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMK_A 42.91 4.0E-63 2.24Å 6UG 2016-12-28
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CNH_A 44.07 2.0E-67 1.84Å 3U9 2014-05-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4YNE_A 43.73 2.0E-61 2.02Å 4EK 2015-06-03
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5IUG_A 43.42 9.0E-69 1.93Å 729 2016-05-18
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKG_A 42.91 3.0E-63 2.53Å 22L GO7 2018-07-11
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_H 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 4IBM_B 74.75 2.0E-130 1.8Å IR1 2013-08-21
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5AA8_A 43.73 6.0E-67 1.86Å 5P8 2016-06-08
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5JFW_A 43.73 2.0E-61 1.52Å 6K2 2017-03-01
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6D1Y_A 42.91 3.0E-63 1.93Å FQJ 2018-05-02
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) IRS1 (P35568) HUMAN 2Z8C_A 74.26 0 3.25Å S91 2008-08-12
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1IR3_A 74.26 0 1.9Å ANP 1998-01-07
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_F 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) NTRK2 (Q16620) - HUMAN 4AT5_A 42.71 2.0E-62 1.71Å MUJ 2012-08-22
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01318), INS (P01308) HUMAN 6CE7_B 49.24 0 7.4Å - 2018-03-14
Protein tyrosine kinase (100%) (view alignment) NTRK2 (Q16620) - HUMAN 4AT4_A 42.71 2.0E-62 2.36Å T6E 2012-08-22
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1P14_A 74.26 1.0E-130 1.9Å - 2003-07-22
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKI_A 42.91 3.0E-63 2.11Å GOD 22L 2018-07-11
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) Insr (P15127) HUMAN 4XST_E 55.52 5.0E-96 3Å NAG FUC 2015-06-10
Protein tyrosine kinase (99%) (view alignment) NTRK3 (Q16288) - HUMAN 6KZD_A 41.58 1.0E-57 1.708Å DZ6 2019-10-09
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_B 76.97 0 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2X2M_A 40.14 4.0E-57 2.5Å X2M 2010-02-09
Receptor L domain (100%), Furin-like cysteine rich region (100%), Protein tyrosine kinase (100%) (view alignment) INSR (P06213) (A6XGL2) HUMAN 6PXV_A 53.87 0 3.2Å - 2019-09-04
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5JFX_A 43.73 2.0E-61 1.63Å 6K4 2017-03-01
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 6NJA_A 40.14 4.0E-57 1.92Å ADE 2019-06-05
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5IMX_A 44.07 2.0E-67 2.12Å CZ4 2016-05-04
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CMT_A 44.07 2.0E-67 1.73Å GWH 2014-05-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5JFS_A 43.73 2.0E-61 1.66Å 6K0 2017-03-01
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2IVT_A 40.14 4.0E-57 2.6Å AMP 2006-08-14
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5WR7_A 42.91 3.0E-63 2.76Å RCH 2017-12-06
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FNX_A 43.09 3.0E-68 1.7Å - 2012-08-29
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4PMS_A 43.73 2.0E-61 2.8Å 31X 2014-06-18
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01318), INS (P01308) HUMAN 6CEB_B 49.67 0 4.7Å NAG BMA FUC 2018-03-14
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 4XLV_A 73.75 0 2.3Å ACP 2015-03-25
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6PL1_A 42.91 5.0E-63 2.03Å OOJ 2019-10-09
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6J5L_A 43.73 2.0E-61 2.3Å B9C 2019-07-17
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) PTPN1 (P18031) HUMAN 2B4S_B 74.59 0 2.3Å - 2005-11-15
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMM_A 42.91 4.0E-63 2.117Å 6UJ 2016-12-28
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) GRB14 (Q14449) HUMAN 2AUH_A 74.59 0 3.2Å - 2005-11-01
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_S 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 2ZM3_B 77.78 0 2.27Å 575 2008-06-10
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3O23_A 77.38 0 2.1Å MQY 2011-05-04
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01318), INS (P01308) HUMAN 6CE9_B 49.67 0 4.3Å NAG BMA FUC 2018-03-14
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5AAB_A 43.73 6.0E-67 2.2Å VGH 2016-06-08
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LVP_C 74.7 0 3Å PDR 2010-07-21
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3NW6_A 77.7 0 2.2Å LGW 2010-07-28
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) IGF1R (P08069) IGF1 (P05019) HUMAN 5U8Q_A 51.84 0 3.27Å NAG MAN MLT 2018-02-28
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 3AOX_A 43.46 7.0E-69 1.75Å EMH 2011-05-25
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 6NEC_A 40.14 4.0E-57 1.87Å XIN 2019-06-05
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5AA9_A 43.73 4.0E-67 1.77Å 5P8 2016-06-08
Protein tyrosine kinase (100%) (view alignment) NTRK2 (Q16620) - HUMAN 4AT3_A 42.71 2.0E-62 1.77Å LTI 2012-08-22
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_C 39.44 1.0E-56 2.58Å PGE 2016-03-30
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Sh2b2 (Q9Z200) HUMAN 1RQQ_B 74.59 0 2.6Å - 2003-12-30
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) INS (P01308) HUMAN 4OGA_E 55.52 5.0E-96 3.5Å NAG BMA MAN FUC 2014-08-27
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CD0_A 43.69 2.0E-68 2.23Å AWJ 2014-01-29
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KML_A 42.91 4.0E-63 2.01Å 6UH 2016-12-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3D94_A 77.74 0 2.3Å D94 2008-07-29
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5FXQ_A 77.85 0 2.3Å GD5 2016-10-19
Protein tyrosine kinase (100%) (view alignment) ROS1 (P08922) - HUMAN 3ZBF_A 46.6 3.0E-65 2.12Å VGH 2013-06-12
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LW0_C 76.97 0 1.79Å CCX 2010-09-29
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_C 76.97 0 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3QQU_B 77.93 0 2.9Å 01P 2011-04-20
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_E 76.97 0 2.2Å 66A MES 2016-04-06
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) GCN4 (P03069), INSR (P06213) - HUMAN, BAKER'S YEAST 6HN4_F 49.94 0 4.2Å NAG 2018-11-21
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4ANL_A 43.04 2.0E-67 1.7Å - 2013-03-27
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2X2K_A 40.14 4.0E-57 2.6Å X2K 2010-02-09
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2YJR_A 43.04 2.0E-67 1.8Å - 2012-06-06
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_A 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6D20_A 42.91 3.0E-63 1.94Å FQG FQD 2018-05-02
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1P4O_B 77.64 0 1.5Å - 2003-04-29
Receptor L domain (100%), Furin-like cysteine rich region (100%), Protein tyrosine kinase (100%) (view alignment) INSR (P06213) (A6XGL2) HUMAN 6PXV_C 53.87 0 3.2Å - 2019-09-04
Protein tyrosine kinase (100%) (view alignment) Musk (Q62838) - NORWAY RAT 1LUF_A 42.56 8.0E-64 2.05Å - 2002-09-11
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) - 4ZXB_E 49.94 0 3.3Å NAG BMA FUC MAN 2016-02-24
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKW_B 43.73 2.0E-61 2.91Å GXA 2018-07-11
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6PL3_A 42.91 5.0E-63 3Å OOD 2019-09-04
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2IVS_B 40.14 4.0E-57 2Å ACK 2006-08-14
Receptor L domain (100%), Furin-like cysteine rich region (100%), Protein tyrosine kinase (100%) (view alignment) INSR (P06213) (A6XGL2) HUMAN 6PXW_B 53.87 0 3.1Å - 2019-09-04
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_A 39.44 1.0E-56 2.58Å - 2016-03-30
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5AM7_A 39.44 2.0E-56 1.957Å 38O 2015-03-18
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LVP_B 74.7 0 3Å PDR 2010-07-21
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 5AMN_A 42.14 2.0E-59 2.57Å DTQ 2016-02-17
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FOD_A 43.46 5.0E-69 2Å 0UV 2012-07-11
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FNY_A 43.09 3.0E-68 2.45Å I3K 2012-08-29
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5IUH_A 43.42 9.0E-69 2.1Å 34Y 2016-05-18
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2YJS_A 43.37 7.0E-68 1.84Å - 2012-06-06
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) IGF1R (P08069) - HUMAN 1IGR_A 55.08 0 2.6Å NAG BMA FUC MAN 1999-09-27
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 6EDL_A 44.07 1.0E-67 2.8Å J4M 2019-05-01
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 2ZM3_C 77.78 0 2.27Å 575 2008-06-10
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CTB_A 44.07 2.0E-67 1.73Å KVC 2014-05-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_C 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_J 77.78 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (99%) (view alignment) NTRK1 (P04629) - HUMAN 5I8A_A 44.16 3.0E-61 2.33Å 69C 2017-08-09
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2XP2_A 44.07 2.0E-67 1.86Å VGH 2010-09-15
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3QQU_D 77.93 0 2.9Å 01P 2011-04-20