Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

rpl5 (P14124) - Overview - Molecular Target Synopsis

Protein


rpl5, 50S ribosomal protein L5
UniProt P14124

Also Known as RL5_HALMA, rpl5

This is 1 of 5 proteins that mediates the attachment of the 5S rRNA onto the large ribosomal subunit, stabilizing the orientation of adjacent RNA domains. Forms part of the central protuberance. Modeling places the A and P site tRNAs in close proximity to this protein; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. In the 70S ribosome it is thought to contact protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Part of the 50S ribosomal subunit. Interacts with protein L18 and the 5S rRNA, and probably with tRNAs. Forms a bridge to the 30S subunit in the 70S ribosome.

3OW2
CRYSTAL STRUCTURE OF ENHANCED MACROLIDE BOUND TO 50S RIBOSOMAL SUBUNIT
RCSB/PDB
Inspect Structure
See all 3D Structures for rpl5

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
177P14124-1

Sub-cellular localization


GO terms: rpl5 is active in the following subcellular-locations: ribosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rpl5 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rpl5 there are:
68 structures (68 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis