Molecular Target Synopsis
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HSD17B1 (P14061) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed39
Chains with at least one site assessed as druggable using the strict criteria39
Chains with at least one site assessed as druggable using the relaxed criteria39


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1DHT_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 72.2 48.8 Yes Yes
2 empty 1.98 61.4 29.4 No No
3 empty 1.92 64.1 19.4 No No
4 empty 1.9 68.2 27.3 No No
5 empty 2.32 59.1 24.6 No No
6 empty 2.26 70.4 13.1 No No
7 empty 1.74 69 11.1 No No
8 empty 1.99 70.1 8.1 No No
9 empty 2.53 75.5 10.4 No No
10 empty 1.72 76 10.1 No No
6MNE_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 76.4 36.1 Yes Yes
2 empty 2 60 33.2 No No
3 empty 2.36 58.7 21.9 No No
4 empty 1.8 65.7 25.8 No No
5 empty 2.02 64 18.1 No No
6 empty 1.96 68.3 19.4 No No
7 empty 2.11 67 19.2 No No
8 empty 2.41 73.6 15.8 No No
9 empty 1.76 67.1 11.3 No No
10 empty 2.19 69 11 No No
3DEY_X Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 78 39 Yes Yes
2 empty 2.15 56 23.5 No No
3 empty 1.82 53.1 21.7 No No
4 empty 1.13 61.6 13.1 No No
5 empty 1.73 61.3 14.5 No No
6 empty 1.74 75.2 11.7 No No
7 empty 2.17 62 13.7 No No
8 empty 1.96 60.7 14.5 No No
9 bound 1.93 63 11.6 No No
10 empty 1.85 61.3 13 No No
3KLP_X Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 75.2 38.1 Yes Yes
2 empty 2 62.2 26.7 No No
3 empty 2.19 61 24.6 No No
4 empty 1.85 59.9 24.4 No No
5 empty 1.72 63.1 20.9 No No
6 empty 1.75 77 11.6 No No
7 empty 1.67 69.4 9.3 No No
8 empty 2.04 71.1 7.6 No No
9 empty 2.36 60 12.8 No No
10 empty 2.1 56.6 11 No No
6CGE_B Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 78.3 37.4 Yes Yes
2 empty 1.89 60 22.8 No No
3 empty 1.75 67.4 21.7 No No
4 empty 1.92 63.6 15.6 No No
5 empty 2.13 65.3 17.6 No No
6 empty 1.98 56.2 19.5 No No
7 empty 2.4 60.4 13.5 No No
8 empty 1.8 71.8 9.2 No No
9 empty 2.42 75.5 12.1 No No
10 empty 2.11 53.8 12.8 No No
1BHS_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.62 79.2 40.2 Yes Yes
2 empty 1.7 65.9 17.5 No No
3 empty 2.04 62.1 18.2 No No
4 empty 1.88 67.6 22.1 No No
5 empty 2.08 66.2 21.5 No No
6 empty 2.29 59.6 21.6 No No
7 empty 1.83 74.8 11.6 No No
8 empty 1.79 60.2 15.7 No No
9 empty 1.69 68.6 8.9 No No
10 empty 2.2 67.5 10.3 No No
6MNC_B Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 83.1 24.4 Yes Yes
2 empty 1.96 56.7 28.2 No No
3 empty 1.95 66.3 25.2 No No
4 empty 1.82 63.4 16.7 No No
5 empty 1.9 66.2 18.7 No No
6 empty 2.5 65.1 18.4 No No
7 empty 2.59 68.9 12.9 No No
8 empty 2.25 52.1 16.3 No No
9 empty 2.28 57.8 19.8 No No
10 empty 2.4 63.5 15 No No
1FDV_D Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 77.7 42.6 Yes Yes
2 empty 1.87 65 21.9 No No
3 empty 2.23 55.2 23.6 No No
4 empty 2.15 63.1 17.5 No No
5 empty 1.7 61.3 16.5 No No
6 empty 1.96 63.7 21.3 No No
7 empty 1.61 73.2 15.1 No No
8 empty 1.68 51.2 17.1 No No
9 empty 2.34 66.1 17.3 No No
10 empty 1.53 68.8 11 No No
6MNC_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 79.1 45.4 Yes Yes
2 empty 1.81 66.5 21.5 No No
3 bound 1.87 60.4 20.4 No No
4 empty 1.78 64 17.5 No No
5 empty 1.94 63.3 17.9 No No
6 empty 2.31 68.9 12.7 No No
7 empty 2.04 69.6 18 No No
8 empty 2.12 64.6 19.4 No No
9 empty 2.22 53.1 12.6 No No
10 empty 1.61 64.9 9.5 No No
6DTP_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 71 43.3 Yes Yes
2 bound 2.39 65.6 29.2 No No
3 bound 1.73 65.4 22.1 No No
4 bound 1.78 62.7 18.4 No No
5 empty 2.26 73.6 15.1 No No
6 empty 1.88 71.9 12 No No
7 bound 1.72 61.2 12.3 No No
8 empty 1.75 68.5 11.9 No No
9 empty 2.09 54.7 12.6 No No
10 bound 1.84 59 11.3 No No
1QYV_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 78.5 37.9 Yes Yes
2 bound 1.94 68.5 24.6 No No
3 empty 1.55 64.4 20.8 No No
4 empty 1.93 63.6 19.6 No No
5 empty 2.34 64 22.9 No No
6 empty 1.78 60.1 19.2 No No
7 empty 2.24 67.2 22.7 No No
8 empty 2.3 69.9 13.5 No No
9 empty 1.78 55.2 16 No No
10 empty 2.34 66.6 19 No No
1FDV_C Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 74.8 42.2 Yes Yes
2 empty 1.95 58 26.7 No No
3 empty 1.98 66.1 24.1 No No
4 empty 1.92 61.7 24.1 No No
5 empty 2.34 60.7 14.5 No No
6 empty 1.67 74.2 12.3 No No
7 empty 2 69.9 15 No No
8 empty 2.46 72.2 13 No No
9 empty 1.62 68 9 No No
10 empty 2.19 57.4 12.4 No No
6CGC_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 74.9 40.8 Yes Yes
2 empty 2.36 60.5 20.3 No No
3 empty 1.9 67.8 24 No No
4 empty 1.9 66 18.3 No No
5 empty 1.74 67.4 16.1 No No
6 empty 2.26 62.6 18.5 No No
7 empty 2.31 76.3 13.7 No No
8 empty 1.98 68.3 13.9 No No
9 empty 1.78 67.8 11.9 No No
10 empty 1.64 58.8 11.8 No No
1FDU_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 89 35.9 Yes Yes
2 bound 2.25 60.8 20.1 No No
3 empty 1.61 62.9 16.8 No No
4 empty 1.88 67.4 13.3 No No
5 empty 1.78 63.1 17.6 No No
6 empty 1.59 64.1 13.9 No No
7 empty 2.03 66.5 10.6 No No
8 empty 1.64 68.8 11.3 No No
9 empty 1.49 54.6 15.3 No No
10 empty 1.73 61.4 13.1 No No
1QYW_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 77.7 37.7 Yes Yes
2 empty 1.89 61.3 32 No No
3 bound 1.82 68.9 20.3 No No
4 empty 1.8 66 19.5 No No
5 empty 2.49 64.1 22.9 No No
6 empty 2.3 70.9 14 No No
7 empty 1.94 58.4 20.8 No No
8 empty 2.21 62 21.9 No No
9 empty 2.06 61.6 20.2 No No
10 empty 2.44 66.7 13.5 No No
1A27_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 74.6 44.9 Yes Yes
2 empty 1.78 65.1 21.2 No No
3 empty 1.77 67.3 14.5 No No
4 empty 2.53 63.8 19.4 No No
5 empty 1.96 61.1 19.3 No No
6 empty 1.87 76.9 10.3 No No
7 empty 1.98 68.8 14.5 No No
8 empty 2.69 61.2 19.3 No No
9 empty 1.72 69.9 10 No No
10 empty 2.06 70.3 13.5 No No
3HB4_X Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 75.5 43.7 Yes Yes
2 empty 2.44 65.5 33.1 No No
3 empty 1.84 60.3 20.6 No No
4 empty 1.63 67.6 16 No No
5 empty 2.45 64.1 22.1 No No
6 empty 2.25 66.1 21.3 No No
7 empty 1.53 64.6 15.9 No No
8 empty 1.94 78.2 13 No No
9 empty 1.97 73 12 No No
10 empty 1.73 67.9 9.7 No No
6MNE_B Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 73.1 39.4 Yes Yes
2 empty 2.01 68.4 18.9 No No
3 empty 1.94 67.7 22.2 No No
4 empty 2.54 60.1 23.1 No No
5 empty 1.96 63.4 16.6 No No
6 empty 2.27 63.4 14.7 No No
7 empty 1.8 75 11 No No
8 empty 1.58 68 10.7 No No
9 empty 1.97 67.9 10.2 No No
10 empty 2.16 50.6 12.4 No No
3KLM_X Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 78 39 Yes Yes
2 empty 2.15 56 23.5 No No
3 empty 1.82 53.1 21.7 No No
4 empty 1.13 61.6 13.1 No No
5 empty 1.73 61.3 14.5 No No
6 empty 1.74 75.2 11.7 No No
7 empty 2.17 62 13.7 No No
8 empty 1.96 60.7 14.5 No No
9 bound 1.93 63 11.6 No No
10 empty 1.85 61.3 13 No No
1FDS_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 73.4 42.7 Yes Yes
2 empty 2.01 61.4 32.9 No No
3 empty 1.76 64.1 22.9 No No
4 empty 2.37 64.2 14.7 No No
5 empty 1.98 67.6 14.2 No No
6 empty 2.4 64 17.5 No No
7 empty 1.79 75.6 12.8 No No
8 empty 1.71 68.2 12.2 No No
9 empty 1.97 71.7 7 No No
10 empty 2.7 73.1 10.8 No No
6CGC_B Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 75 41.4 Yes Yes
2 empty 2.28 65.9 28.7 No No
3 empty 1.93 61.5 25.8 No No
4 empty 2.39 65.1 20.3 No No
5 empty 1.71 66.5 18.9 No No
6 empty 1.99 59.6 22.5 No No
7 empty 2.16 73.6 13.6 No No
8 empty 1.81 65.5 11.5 No No
9 empty 1.96 69.8 9.8 No No
10 empty 2.42 48.7 12.9 No No
3KM0_B Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 70.7 41.5 Yes Yes
2 empty 1.96 67.9 25.2 No No
3 empty 1.93 60 21.8 No No
4 empty 2.52 65.5 22.5 No No
5 empty 2.22 62.4 13.8 No No
6 empty 2.62 58.6 20.3 No No
7 empty 1.72 75.7 10.9 No No
8 empty 1.53 64.5 10.7 No No
9 empty 2.24 58.6 11.1 No No
10 empty 2.01 68.1 11.8 No No
1I5R_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 75.8 41.5 Yes Yes
2 bound 1.92 63.7 37.3 No No
3 empty 1.99 62.7 22.5 No No
4 empty 2.11 64.7 15.2 No No
5 empty 1.94 73 10.6 No No
6 empty 2.35 70.3 10.7 No No
7 empty 1.57 68 7.8 No No
8 empty 2.13 73.1 11.2 No No
9 empty 2.81 58.9 10 No No
10 empty 2.33 59.9 7.3 No No
6DTP_B Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 79.3 41 Yes Yes
2 empty 2.3 68.1 26.4 No No
3 bound 2.06 60.4 33.7 No No
4 empty 1.76 65.1 16.9 No No
5 empty 2 65.9 18.1 No No
6 empty 2.22 65.7 22.7 No No
7 bound 2.33 73.2 13.8 No No
8 empty 1.72 65.8 10.5 No No
9 bound 1.79 54.7 14.8 No No
10 empty 2.36 60.1 10.8 No No
1EQU_B Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 82.5 28.7 Yes Yes
2 empty 2.19 66.4 31.4 No No
3 empty 1.84 65 31 No No
4 empty 1.81 67 21.4 No No
5 empty 1.59 62.5 19.2 No No
6 empty 2.69 64.4 32.6 No No
7 empty 2.28 70.4 14.5 No No
8 empty 2.3 65.5 21.8 No No
9 empty 1.97 67.1 16.2 No No
10 empty 1.64 52.7 13.7 No No
1EQU_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 76.7 40.8 Yes Yes
2 empty 1.78 63.9 29 No No
3 empty 2.07 66.6 12.9 No No
4 empty 1.9 63.1 25.5 No No
5 empty 2.31 68.3 16.8 No No
6 empty 1.9 72.5 13.7 No No
7 empty 2.09 62.3 17.6 No No
8 empty 2.15 65.5 16.3 No No
9 empty 2 62.1 16.9 No No
10 empty 1.79 58.4 10.7 No No
1FDV_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 80.6 30.6 Yes Yes
2 empty 2.17 66.4 18.3 No No
3 empty 1.9 69.5 13.8 No No
4 empty 1.6 60.4 18.5 No No
5 empty 1.81 61.7 14.3 No No
6 empty 1.36 64.2 14.2 No No
7 empty 1.44 70.5 12.1 No No
8 empty 1.89 66 11 No No
9 empty 1.5 50.1 14.3 No No
10 empty 2.34 72.2 10.5 No No
1FDU_B Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 87.5 39.3 Yes Yes
2 empty 2.2 61.8 24.6 No No
3 empty 1.83 71.1 16.9 No No
4 bound 2.25 60.1 19 No No
5 empty 1.64 64.7 13.3 No No
6 empty 1.11 62.2 13.6 No No
7 empty 1.93 50.3 14.1 No No
8 empty 2.27 61.1 12.1 No No
9 empty 1.98 63.2 15 No No
10 empty 2.2 55.7 16.5 No No
1FDT_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 75.5 40 Yes Yes
2 empty 1.88 67.2 23 No No
3 empty 1.91 65.4 31.8 No No
4 empty 2.07 63.7 18.2 No No
5 bound 1.9 59.9 20.7 No No
6 empty 2.39 61 24.6 No No
7 empty 2.42 70.4 12.3 No No
8 empty 1.78 73.6 11.4 No No
9 empty 1.62 66.4 12 No No
10 empty 2.15 76.1 7.1 No No
3HB5_X Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 77.8 44.2 Yes Yes
2 empty 1.86 62.4 26.5 No No
3 empty 1.69 67 18.2 No No
4 empty 2.43 62.4 23.9 No No
5 empty 1.67 62.1 18.8 No No
6 empty 1.93 57.2 16.7 No No
7 empty 2.09 70.6 12.2 No No
8 empty 2.09 69.6 16 No No
9 empty 1.87 74.1 11.4 No No
10 empty 1.96 75.4 11.5 No No
1FDW_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 74.1 41.8 Yes Yes
2 empty 2.47 67.9 34.4 No No
3 empty 1.99 63.5 19.7 No No
4 empty 1.91 65.2 29.4 No No
5 empty 1.81 64.6 18.1 No No
6 empty 2.01 63.3 21.3 No No
7 empty 1.83 73.5 18.7 No No
8 empty 1.43 67.5 13.6 No No
9 empty 2.33 64.8 16.6 No No
10 empty 1.77 62.5 16.9 No No
1FDU_D Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 79.2 37.1 Yes Yes
2 empty 1.95 65.2 17.2 No No
3 empty 1.39 64.7 14.6 No No
4 empty 1.86 63.3 20.1 No No
5 empty 1.62 61.7 16.3 No No
6 empty 1.67 70.9 11.7 No No
7 empty 2.2 53.7 15.8 No No
8 empty 1.54 52.4 14.6 No No
9 empty 1.76 65.2 9.7 No No
10 empty 1.58 62.5 11.3 No No
1FDU_C Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 76.3 39.9 Yes Yes
2 empty 2.17 64.6 14.1 No No
3 empty 1.65 61 16.9 No No
4 empty 1.55 73.6 12.6 No No
5 empty 1.11 64.8 12.8 No No
6 empty 1.71 61.7 15.4 No No
7 empty 2.11 66 13.4 No No
8 empty 1.55 52.6 14.1 No No
9 empty 2.22 61.3 12.6 No No
10 empty 1.76 63.9 9.7 No No
1IOL_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 74.6 49.7 Yes Yes
2 empty 1.82 60.6 22.2 No No
3 empty 1.87 67.4 28 No No
4 empty 1.9 67.8 19.7 No No
5 empty 2.17 63.3 24.7 No No
6 empty 2.19 64.1 18.1 No No
7 empty 2.28 66.9 13.1 No No
8 empty 1.69 63.2 10.8 No No
9 empty 2.22 68.4 13.3 No No
10 empty 2.18 74.2 9.9 No No
1QYX_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 82 20.6 Yes Yes
2 empty 1.87 55.4 21.1 No No
3 empty 1.67 66.5 20.4 No No
4 empty 1.92 60.7 20.8 No No
5 empty 2.03 61.7 20.3 No No
6 empty 1.13 61.4 12.8 No No
7 empty 2.28 59.9 16.7 No No
8 empty 2.19 67.3 12.8 No No
9 empty 2.09 54.1 14.4 No No
10 empty 1.93 53.2 13.3 No No
1FDV_B Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 75.5 42.8 Yes Yes
2 empty 1.9 67.7 19.9 No No
3 empty 1.79 63.7 25.6 No No
4 empty 2.1 63.4 19.8 No No
5 empty 1.67 70.9 14.2 No No
6 empty 2.02 54.2 13.1 No No
7 empty 2.14 69.4 16.3 No No
8 empty 2.52 59.5 16.8 No No
9 empty 2.61 82.7 13 No No
10 empty 2.61 59.5 12.2 No No
3DHE_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 75.2 40.6 Yes Yes
2 empty 1.84 67.4 23.9 No No
3 empty 1.89 61.3 24.3 No No
4 empty 1.91 64.3 20.2 No No
5 empty 2.28 63 23.5 No No
6 empty 2.07 66.5 20.5 No No
7 empty 2.11 64.9 20.7 No No
8 empty 2.12 66.7 15.9 No No
9 empty 1.62 62.6 10.7 No No
10 empty 2.16 73.4 11.7 No No
1JTV_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 82.2 21.4 Yes Yes
2 empty 1.92 55.3 27.8 No No
3 empty 1.82 60.8 19.5 No No
4 empty 1.96 56.8 19.4 No No
5 empty 2.2 61 23.2 No No
6 empty 1.11 64.1 13.2 No No
7 empty 2.3 63.8 11.5 No No
8 empty 2.12 51.9 12.8 No No
9 empty 1.87 61.1 14.7 No No
10 empty 2.26 70.5 11.1 No No
3KM0_A Estradiol 17-beta-dehydrogenase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 75.3 39.9 Yes Yes
2 empty 2.02 65 34.4 No No
3 empty 2.05 56.9 33.7 No No
4 empty 2.01 63 16 No No
5 empty 1.8 68 17.5 No No
6 empty 2.3 60.7 14.4 No No
7 empty 1.84 74.8 11.8 No No
8 empty 2.29 61 15.9 No No
9 empty 1.57 66.9 11.4 No No
10 empty 2.08 50.3 15 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed35
Domains assessed as druggable using the strict criteria35
Domains assessed as druggable using the relaxed criteria35

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1A27_A (29839) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.9Å Yes Yes
1BHS_A (29840) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.2Å Yes Yes
1DHT_A (29843) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2Å Yes Yes
1EQU_A (4180563) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 3Å Yes Yes
1EQU_B (29847) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 3Å Yes Yes
1EQU_A (29846) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 3Å Yes Yes
1EQU_B (4180563) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 3Å Yes Yes
1FDS_A (29838) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.7Å Yes Yes
1FDT_A (29841) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.15Å Yes Yes
1FDU_B (29849) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.7Å Yes Yes
1FDU_C (4213126) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.7Å Yes Yes
1FDU_D (29851) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.7Å Yes Yes
1FDU_A (4060361) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.7Å Yes Yes
1FDU_D (4213126) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.7Å Yes Yes
1FDU_A (29848) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.7Å Yes Yes
1FDU_B (4060361) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.7Å Yes Yes
1FDU_C (29850) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.7Å Yes Yes
1FDV_B (4047140) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 3Å Yes Yes
1FDV_D (29855) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 3Å Yes Yes
1FDV_C (29854) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 3Å Yes Yes
1FDV_B (29853) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 3Å Yes Yes
1FDV_A (29852) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 3Å Yes Yes
1FDV_A (4047140) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 3Å Yes Yes
1FDV_C (4164456) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 3Å Yes Yes
1FDV_D (4164456) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 3Å Yes Yes
1FDW_A (29845) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.7Å Yes Yes
1I5R_A (83668) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.6Å Yes Yes
1IOL_A (29842) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.3Å Yes Yes
1JTV_A (84230) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.54Å Yes Yes
1QYV_A (104659) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.81Å Yes Yes
1QYW_A (104660) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.63Å Yes Yes
1QYX_A (104661) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.89Å Yes Yes
3DEY_X (3360209) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, UNMATCHED 1.7Å Yes Yes
3DHE_A (29844) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.3Å Yes Yes
3HB4_X (3450651) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, UNMATCHED 2.21Å Yes Yes
3HB5_X (3450653) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, UNMATCHED 2Å Yes Yes
3KLM_X (3510126) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, UNMATCHED 1.7Å Yes Yes
3KLP_X (3620693) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, UNMATCHED 2.5Å Yes Yes
3KM0_A (4177017) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.3Å Yes Yes
3KM0_A (3620697) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, UNMATCHED 2.3Å Yes Yes
3KM0_B (4177017) Estradiol 17-beta-dehydrogenase 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.3Å Yes Yes
Ligand-based Druggability Score: 0.75
Ligand-based Druggability Score Percentile: 88%
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score