Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNA Interference
Mutations

HSD3B1 (P14060) - Overview - Molecular Target Synopsis

Protein


HSD3B1, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Enzyme Classification 1.1.1.145
UniProt P14060

Also Known as 3BHS1_HUMAN, HSD3B1, 3BH, HSDB3A

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.

Isoforms / Transcripts (Protein Coding)


Drugs


HSD3B1 is targeted by Approved Drug Trilostane. (see details)

Sub-cellular localization


UniProt: HSD3B1 is active in the following subcellular-locations: endoplasmic reticulum membrane, mitochondrion membrane.
GO terms: HSD3B1 is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of membrane, mitochondrial inner membrane, mitochondrial intermembrane space, smooth endoplasmic reticulum membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HSD3B1 has gain in 4 cell-lines, loss in 3 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, RPMI_8226, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H226, NCI-H2803, RERF-GC-1B

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


HSD3B1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)


Screening and Chemistry


HSD3B1 has been screened with 15 compounds (15 bioactivities), 12 compounds have bioactivities that show binding affinity of <= 500nM (12 bioactivities). (see details)