Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(P13922) - Overview - Molecular Target Synopsis

Protein


, Bifunctional dihydrofolate reductase-thymidylate synthase
Enzyme Classification 1.5.1.3
UniProt P13922

Also Known as DRTS_PLAFK

Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP. Homodimer.

3DGA
WILD-TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH RJF01302, NADPH, AND DUMP
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
608P13922-1

Drugs


is targeted by Approved Drugs Pyrimethamine, Chloroguanide. (see details)
Pyrimethamine
Chloroguanide

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
5 structures (20 chains) solved
5 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

is solved in complex with the approved drug(s):

CP6/PYRIMETHAMINE (1J3J_A, 1J3J_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


has been screened with 157 compounds (1759 bioactivities), 132 compounds have bioactivities that show binding affinity of <= 500nM (656 bioactivities). (see details)