Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACP5 (P13686) - Overview - Molecular Target Synopsis

Protein


ACP5, Tartrate-resistant acid phosphatase type 5
Enzyme Classification 3.1.3.2
UniProt P13686

Also Known as PPA5_HUMAN, ACP5

Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).

2BQ8
CRYSTAL STRUCTURE OF HUMAN PURPLE ACID PHOSPHATASE WITH AN INHIBITORY CONFORMATION OF THE REPRESSION LOOP
RCSB/PDB
Inspect Structure
See all 3D Structures for ACP5

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACP5 is active in the following subcellular-locations: lysosome.
GO terms: ACP5 is active in the following subcellular-locations: cytosol, integral component of membrane, lysosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACP5 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_N, MDA_MB_435, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 853, UACC-257, SK-MEL-28

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, CD20-positive B cell, SK-N-SH

(see details)

3D Structures


For ACP5 there are:
2 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACP5 has been screened with compounds ( bioactivities). (see details)