Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SPT15 (P13393) - Overview - Molecular Target Synopsis

Protein


SPT15, TATA-box-binding protein
UniProt P13393

Also Known as TBP_YEAST, SPT15, BTF1, TBP1

General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. Binds DNA as monomer. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14. Interacts with TFC8.

6E24
TERNARY STRUCTURE OF C-MYC-TBP-TAF1
RCSB/PDB
Inspect Structure
See all 3D Structures for SPT15

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
240P13393-1

Sub-cellular localization


UniProt: SPT15 is active in the following subcellular-locations: nucleus.
GO terms: SPT15 is active in the following subcellular-locations: nucleoplasm, nucleus, protein-containing complex, transcription factor complex, transcription factor TFIIA complex, transcription factor TFIID complex, transcription factor TFIIIB complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SPT15 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For SPT15 there are:
30 structures (35 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis