Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MLN (P12872) - Overview - Molecular Target Synopsis

Protein


MLN, Promotilin
UniProt P12872

Also Known as MOTI_HUMAN, MLN

Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.

1LBJ
22 RESIDUE FRAGMENT OF
MOTILIN
IN THE STRUCTURE OF
NMR SOLUTION STRUCTURE OF MOTILIN IN PHOSPHOLIPID BICELLAR SOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for MLN

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MLN is active in the following subcellular-locations: secreted.
GO terms: MLN is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MLN has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: 786_0, HL_60, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For MLN there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MLN has been screened with 35 compounds (46 bioactivities), 27 compounds have bioactivities that show binding affinity of <= 500nM (36 bioactivities). (see details)