Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rpl7ae (P12743) - Overview - Molecular Target Synopsis

Protein


rpl7ae, 50S ribosomal protein L7Ae
UniProt P12743

Also Known as RL7A_HALMA, rpl7ae

Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. Part of the 50S ribosomal subunit. Interacts with protein L15e. Probably part of the RNase P complex.

3OW2
CRYSTAL STRUCTURE OF ENHANCED MACROLIDE BOUND TO 50S RIBOSOMAL SUBUNIT
RCSB/PDB
Inspect Structure
See all 3D Structures for rpl7ae

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
120P12743-1

Sub-cellular localization


UniProt: rpl7ae is active in the following subcellular-locations: cytoplasm.
GO terms: rpl7ae is active in the following subcellular-locations: ribosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rpl7ae has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rpl7ae there are:
67 structures (67 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis