Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(P12256) - Overview - Molecular Target Synopsis

Protein


, Penicillin acylase
Enzyme Classification 3.5.1.11
UniProt P12256

Also Known as PAC_LYSSH

The enzyme catalyzes the conversion of penicillin to 6-aminopenicillanate The precursor, furthermore, acts as a self-processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase. Homotetramer.

3MJI
ACTIVATION OF CATALYTIC CYSTEINE WITHOUT A BASE IN A MUTANT PENICILLIN ACYLASE PRECURSOR
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
338P12256-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
6 structures (30 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

is solved in complex with the approved drug(s):

PNV/PENICILLIN V (2Z71_A, 2Z71_C).

(see details)
Molecular Target 3D Synopsis