Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FABP2 (P12104) - Overview - Molecular Target Synopsis

Protein


FABP2, Fatty acid-binding protein, intestinal
UniProt P12104

Also Known as FABPI_HUMAN, FABP2, FABPI

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

2MO5
HIFABP-OLEATE COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for FABP2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
132ENSG00000145384ENST00000274024ENSP00000274024
132P12104-1

Sub-cellular localization


UniProt: FABP2 is active in the following subcellular-locations: cytoplasm.
GO terms: FABP2 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FABP2 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_5, TK_10, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-16, SNU-C1, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For FABP2 there are:
6 structures (9 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FABP2 has been screened with 33 compounds (55 bioactivities), 4 compounds have bioactivities that show binding affinity of <= 500nM (8 bioactivities). (see details)