Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SIR4 (P11978) - Overview - Molecular Target Synopsis


SIR4, Regulatory protein SIR4
UniProt P11978

Also Known as SIR4_YEAST, SIR4, ASD1, STE9, UTH2

The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR (PubMed:18039933). The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure (PubMed:18039933). Involves the compaction of chromatin fiber into a more condensed form (PubMed:18039933). Homodimer (PubMed:12791253). Interacts with MPS3 (PubMed:18039933). Interacts with RIS1 (PubMed:9271422). Interacts with SIR1, SIR2 and SIR3 (PubMed:11722841). Interacts with YKU80 (PubMed:14551211). Interacts with UBP10 (PubMed:10490600, PubMed:26149687).

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: SIR4 is active in the following subcellular-locations: nucleus.
GO terms: SIR4 is active in the following subcellular-locations: chromatin silencing complex, chromosome, nuclear chromosome, nuclear telomeric heterochromatin.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SIR4 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures

For SIR4 there are:
3 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis