Molecular Target Synopsis
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parM (P11904) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed52
Chains with at least one site assessed as druggable using the strict criteria51
Chains with at least one site assessed as druggable using the relaxed criteria52


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4A6J_D Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.48 76.2 36.9 Yes Yes
2 empty 2.56 64.7 26.2 No No
3 empty 2.44 62.1 24.8 No No
4 empty 1.68 68.4 14.8 No No
5 empty 2.58 50 20.8 No No
6 empty 2.25 64.8 24.8 No No
7 empty 1.91 63.6 19.8 No No
8 empty 2.12 65.3 20.2 No No
9 empty 2.3 61.6 15.8 No No
10 empty 2.2 63.7 10.4 No No
3IKU_I Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.69 73.8 44.9 Yes Yes
2 empty 2.46 57.3 16.7 No No
3 empty 2.11 61.9 20.2 No No
4 empty 2.25 63.2 20.5 No No
5 empty 2.27 66.7 15.6 No No
6 empty 1.93 66.3 19 No No
7 empty 2.49 75.7 14.8 No No
8 empty 1.94 62.9 18.4 No No
9 empty 2.38 61.2 15.4 No No
10 empty 2.42 65.6 14.3 No No
5AEY_B Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 79 36.1 Yes Yes
2 empty 1.95 62 28 No No
3 empty 2.33 64.5 18.5 No No
4 empty 2.37 69.2 19.7 No No
5 empty 2.13 65.2 24.1 No No
6 empty 2.26 69.6 18.4 No No
7 empty 1.92 58.6 14.5 No No
8 empty 2.33 65.8 15.8 No No
9 empty 2.08 60 17.3 No No
10 empty 2.05 66.7 18.9 No No
2ZGZ_B Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.32 75.4 49.1 Yes Yes
2 empty 2.37 59.5 19.1 No No
3 empty 2.36 60.7 25.7 No No
4 empty 2.41 65.8 20.4 No No
5 empty 2.4 69.6 19.3 No No
6 empty 1.9 62.4 19.2 No No
7 empty 2.67 64 19.2 No No
8 empty 2.03 75 10.2 No No
9 empty 2.2 58.8 12.2 No No
10 empty 2.05 57.9 11.6 No No
1MWM_A Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.63 74.2 45.7 Yes Yes
2 empty 2.52 55.7 25.1 No No
3 empty 2.09 59.5 27.7 No No
4 empty 2.24 66 16 No No
5 empty 2.17 62.2 20.5 No No
6 empty 2.02 65.1 20.4 No No
7 empty 1.97 64.9 18.1 No No
8 empty 2.3 77.3 10.7 No No
9 empty 2.39 61.8 17.7 No No
10 empty 2.4 63.1 14.3 No No
3IKU_B Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.57 74.1 44.1 Yes Yes
2 empty 2.46 55.1 18 No No
3 empty 2.06 62.2 24.3 No No
4 empty 2.1 65.9 15.4 No No
5 empty 2 66.2 18.8 No No
6 empty 2.4 74.7 12.5 No No
7 empty 1.98 64.8 16 No No
8 empty 2.36 71.3 13.6 No No
9 empty 2.41 64.2 16.8 No No
10 empty 2.1 56 17.1 No No
1MWK_A Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.51 69.1 45.7 Yes Yes
2 empty 2.26 59.7 25.9 No No
3 empty 2.24 67.4 20.2 No No
4 empty 1.95 62.5 20.2 No No
5 empty 2.33 72.3 12.8 No No
6 empty 2.19 64.6 19.1 No No
7 empty 2.18 53.5 14.9 No No
8 empty 2.44 76.2 15.1 No No
9 empty 2.59 61.1 13.7 No No
10 empty 2.59 57.9 13.9 No No
4A6J_B Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.5 73.9 38.2 Yes Yes
2 empty 2.44 62 23.3 No No
3 empty 2.5 69.1 22.5 No No
4 empty 1.69 67.7 14.9 No No
5 empty 1.75 67.7 19.6 No No
6 empty 2.25 67 21 No No
7 empty 2.32 49.1 16.4 No No
8 empty 2.41 66.4 19.8 No No
9 empty 2.19 64.5 25.5 No No
10 empty 2.33 64.3 12.5 No No
3IKY_I Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.54 69.1 48.9 Yes Yes
2 empty 2.24 59.7 25.7 No No
3 empty 2.35 67.4 27 No No
4 empty 1.89 62.6 20.1 No No
5 empty 2.4 69.3 14.7 No No
6 empty 2.24 72.3 13.4 No No
7 empty 2.29 66.4 17.4 No No
8 empty 2.58 59.8 15.1 No No
9 empty 2.61 60 13.4 No No
10 empty 2.56 67 15.6 No No
5AEY_D Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.3 75.9 36.3 Yes Yes
2 empty 2.25 62.5 23.8 No No
3 empty 1.88 65.5 18.2 No No
4 empty 2.11 62.4 26.3 No No
5 empty 2.3 70.9 19.2 No No
6 empty 2.28 64.1 16.8 No No
7 empty 2.21 61.2 17.3 No No
8 empty 1.74 60.7 13.6 No No
9 empty 2.86 58.4 18.2 No No
10 empty 2.09 65.2 15.6 No No
3IKY_H Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.52 69.2 46 Yes Yes
2 empty 2.23 60.4 28.1 No No
3 empty 2.39 68.8 18.8 No No
4 empty 2.32 70.8 16.5 No No
5 empty 2.33 54.9 16.4 No No
6 empty 2.11 65.4 15.1 No No
7 empty 2.29 69.6 13.1 No No
8 empty 2.73 57.1 14.1 No No
9 empty 2.45 60.4 15 No No
10 empty 2.56 65.5 15.7 No No
4A6J_G Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.59 72.4 44.1 Yes Yes
2 empty 2.48 63.9 24.9 No No
3 empty 1.94 64.1 18.8 No No
4 empty 2.61 50.9 19.3 No No
5 empty 1.78 65.4 19.9 No No
6 empty 2.27 63.9 19.6 No No
7 empty 2.45 67 18.8 No No
8 empty 2.21 66.8 15.5 No No
9 empty 1.92 70.6 12 No No
10 empty 2.18 61 11.5 No No
3IKU_L Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.67 75.7 45.6 Yes Yes
2 empty 2.49 57.3 18.9 No No
3 empty 2.09 64.3 26.3 No No
4 empty 2.55 69.4 23 No No
5 empty 2.22 64.1 16.2 No No
6 empty 2.04 61 18.7 No No
7 empty 1.93 60.6 18.6 No No
8 empty 2.38 60.4 18.8 No No
9 empty 2.35 67.5 13.2 No No
10 empty 2.18 58.8 16.1 No No
2ZGY_A Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 76.4 46.1 Yes Yes
2 empty 2.24 60.2 26.5 No No
3 empty 2.55 55.2 22.3 No No
4 empty 2.41 69.2 16 No No
5 empty 1.99 64.1 20.5 No No
6 empty 2.53 66.8 26.1 No No
7 empty 2.69 67.1 21 No No
8 empty 2.02 69.9 12.8 No No
9 empty 2.19 65.7 13.3 No No
10 empty 2.04 56.9 12.1 No No
3IKU_F Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.66 73.2 44.7 Yes Yes
2 empty 2.45 52 18.7 No No
3 empty 2.21 63.6 25.3 No No
4 empty 2.24 64.6 15.7 No No
5 empty 1.94 64.6 18.8 No No
6 empty 2.1 61.5 18.5 No No
7 empty 2.35 73.7 12.4 No No
8 empty 2.33 75.9 10.4 No No
9 empty 2.45 62.6 18.9 No No
10 empty 2.17 56.5 10.9 No No
4A6J_E Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.45 72.5 40.3 Yes Yes
2 empty 2.43 62.2 23.2 No No
3 empty 2.47 61.7 34.9 No No
4 empty 1.88 64.4 18.6 No No
5 empty 1.75 65.8 19.8 No No
6 empty 2.19 63.5 24.3 No No
7 empty 2.38 52.9 15 No No
8 empty 2.28 63.1 16.6 No No
9 empty 2.26 66 12.8 No No
10 empty 1.89 68 11.9 No No
1MWK_B Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 72.8 39.4 Yes Yes
2 empty 2.45 65.3 22.9 No No
3 empty 2.37 57.6 19 No No
4 empty 1.91 60.2 21.7 No No
5 empty 2.04 65.4 19.6 No No
6 empty 2.11 63.8 16.2 No No
7 empty 2.18 56.2 17.7 No No
8 empty 2.53 55.4 15.1 No No
9 empty 2.66 62.7 13 No No
10 empty 2.38 72.1 12.8 No No
2ZGZ_A Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.36 75.8 45.2 Yes Yes
2 empty 2.42 58.8 19.2 No No
3 empty 2.28 62.7 26.5 No No
4 empty 2.53 67.9 15.2 No No
5 empty 1.94 63.5 20.3 No No
6 empty 2.53 61.2 17.1 No No
7 empty 2.19 66.7 17 No No
8 empty 2.11 68.9 13.2 No No
9 empty 2.06 61.6 12.1 No No
10 empty 2.27 64.7 11 No No
4A6J_C Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.58 70.1 53 Yes Yes
2 empty 2.5 61.1 25 No No
3 empty 2.2 65.2 30 No No
4 empty 1.76 64.7 15.9 No No
5 empty 2.18 65.5 22.5 No No
6 empty 2.42 54.5 14.9 No No
7 empty 2.31 65.3 15.3 No No
8 empty 2.21 64.4 10.9 No No
9 empty 2.07 56.4 12.2 No No
10 empty 1.83 97.2 0 Yes No
3IKU_J Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.61 74.6 44.4 Yes Yes
2 empty 2.44 55.3 17.5 No No
3 empty 2.11 63.1 26.1 No No
4 empty 2.54 68.9 18.9 No No
5 empty 2.12 63.1 21.1 No No
6 empty 2.05 62.5 18.6 No No
7 empty 1.93 61.3 18 No No
8 empty 2.39 60.8 18.4 No No
9 empty 2.23 71 13.7 No No
10 empty 2.14 56.9 12.4 No No
3IKY_D Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.59 70.2 47.9 Yes Yes
2 empty 2.23 59.1 26.7 No No
3 empty 2.25 67.9 26.9 No No
4 empty 2.43 69.9 14.4 No No
5 empty 2.11 67.3 14.5 No No
6 empty 2.7 61.4 15.5 No No
7 empty 2.81 58.7 13.9 No No
8 empty 2.44 67.8 14.8 No No
9 empty 2.27 51.4 14.5 No No
10 empty 1.77 66.9 10.4 No No
5AEY_A Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.29 78.7 35.7 Yes Yes
2 empty 2.26 59.2 24.6 No No
3 empty 1.75 64.7 16.5 No No
4 empty 2.37 68.4 23.6 No No
5 empty 2.4 67.4 15 No No
6 empty 2.08 60.8 16 No No
7 empty 2.37 70.4 18.2 No No
8 empty 2.18 63.1 18.8 No No
9 empty 1.73 62 13 No No
10 empty 2.07 70.1 10.7 No No
3IKU_A Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.5 75.9 43.9 Yes Yes
2 empty 2.42 54.1 17.4 No No
3 empty 2.08 61 25.1 No No
4 empty 2.53 69.8 20.6 No No
5 empty 2.15 64.2 18.3 No No
6 empty 2.03 62.9 17.9 No No
7 empty 2.01 64.7 17.8 No No
8 empty 2.64 67.9 20 No No
9 empty 2.52 60.3 19.3 No No
10 empty 2.32 71.1 13.5 No No
4A6J_I Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.43 74.1 39.6 Yes Yes
2 empty 2.55 63.3 27.3 No No
3 empty 2.5 61.7 25.1 No No
4 empty 1.75 66.2 14.8 No No
5 empty 2.18 66 23.1 No No
6 empty 1.9 65.2 19.5 No No
7 empty 2.4 52.2 14.4 No No
8 empty 2.23 68.3 14.4 No No
9 empty 2.27 66.4 15 No No
10 empty 2.5 63.2 11.6 No No
3IKY_A Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.51 69.7 44.5 Yes Yes
2 empty 2.23 60.1 25.9 No No
3 empty 2.38 66.4 28.5 No No
4 empty 1.98 69.5 18.7 No No
5 empty 2.29 71.8 14.1 No No
6 empty 2.2 62 16.9 No No
7 empty 2.07 57.1 12.9 No No
8 empty 2.38 70.3 13 No No
9 empty 2.59 60.7 15.3 No No
10 empty 2.57 57.1 15.9 No No
3IKY_C Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.6 68.6 52.1 Yes Yes
2 empty 2.24 60.9 25.8 No No
3 empty 2.37 67.8 28.5 No No
4 empty 1.96 64.5 19.9 No No
5 empty 2.14 65.1 19.6 No No
6 empty 2.22 71.7 12.6 No No
7 empty 2.8 57.1 14.7 No No
8 empty 2.59 59.1 11.8 No No
9 empty 2.52 62.6 14.7 No No
10 empty 2.11 68.7 10.1 No No
4A62_B Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.31 80 35.3 Yes Yes
2 empty 2.55 64.1 25 No No
3 empty 1.88 64.5 17.7 No No
4 empty 2.29 62.5 22.9 No No
5 empty 2.18 65.7 20.1 No No
6 empty 2.38 66.8 14.2 No No
7 empty 1.78 66 16 No No
8 empty 2.08 67.3 12.9 No No
9 empty 2.3 58.4 19.1 No No
10 empty 2.26 61.4 19.8 No No
4A6J_H Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.45 73.3 37.9 Yes Yes
2 empty 2.58 65.5 24.1 No No
3 empty 2.25 69 31.3 No No
4 empty 2.37 62 26 No No
5 empty 1.63 66.3 13.8 No No
6 empty 2.15 64.6 25 No No
7 empty 2.39 50.5 15.9 No No
8 empty 2.46 62.3 20.3 No No
9 empty 2.12 66.3 19.6 No No
10 empty 2.19 62.5 10.8 No No
4A6J_F Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.46 72.6 36.3 Yes Yes
2 empty 2.48 64.8 20 No No
3 empty 2.4 61.2 24.3 No No
4 empty 1.69 66.4 14.5 No No
5 empty 2.43 49.3 20.9 No No
6 empty 1.76 62.6 19.5 No No
7 empty 2.28 65.4 21.6 No No
8 empty 2.45 63.7 20.8 No No
9 empty 2.24 63.9 21.6 No No
10 empty 1.95 68.9 14.5 No No
4A6J_A Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.46 75.3 38.5 Yes Yes
2 empty 2.48 61.7 26.9 No No
3 empty 2.14 66.9 26.6 No No
4 empty 2.49 67.1 20.8 No No
5 empty 1.94 64.1 18.3 No No
6 empty 2.55 55.6 16.7 No No
7 empty 2.28 62.4 21.5 No No
8 empty 2.34 65.9 16.7 No No
9 empty 2.39 61.2 12.7 No No
10 empty 2.07 69.7 11.2 No No
4A6J_J Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.45 75.2 39.4 Yes Yes
2 empty 2.39 60.5 24.3 No No
3 empty 2.2 65.5 20.1 No No
4 empty 2.35 64.2 18.1 No No
5 empty 1.69 67.6 14.1 No No
6 empty 2.48 51.4 20.1 No No
7 empty 2.17 62.9 24.3 No No
8 empty 2.29 61.8 16.1 No No
9 empty 2.37 60.1 12.9 No No
10 empty 1.91 71.3 11.3 No No
3IKY_E Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.54 69.1 47.7 Yes Yes
2 empty 2.23 62 25.6 No No
3 empty 2.09 63.3 28.2 No No
4 empty 2.08 63.4 14.2 No No
5 empty 2.33 68.6 15.8 No No
6 empty 2.57 61.7 15.2 No No
7 empty 2.44 71.9 13.1 No No
8 empty 2.49 61 11.7 No No
9 empty 2.28 57.1 12.2 No No
10 empty 2 56 12.5 No No
4A62_A Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.41 72.2 40.5 Yes Yes
2 empty 2.63 63.8 30.3 No No
3 empty 2.37 60.9 25.4 No No
4 empty 1.79 62.9 15.4 No No
5 empty 2.65 51.2 21.4 No No
6 empty 2.17 66.2 18.8 No No
7 empty 1.76 63.6 17.4 No No
8 empty 2.44 65.7 15.5 No No
9 empty 2.19 61.9 11.7 No No
10 empty 2.29 53.7 13.3 No No
3IKU_H Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.5 74.2 44.2 Yes Yes
2 empty 2.45 50.2 18.6 No No
3 empty 2.05 61.8 27.4 No No
4 empty 1.96 65.1 18.8 No No
5 empty 2.24 63.2 19.8 No No
6 empty 2.73 65.9 22.5 No No
7 empty 1.94 63.2 15.9 No No
8 empty 2.28 74.7 10.7 No No
9 empty 2.23 70.6 12.1 No No
10 empty 2.46 62.3 15.7 No No
2ZHC_A Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 78.9 33.9 Yes Yes
2 empty 2.3 64 29.3 No No
3 empty 1.96 65.3 20.4 No No
4 empty 1.85 58.9 18.6 No No
5 empty 2.07 67.2 22.4 No No
6 empty 2.19 59.4 19.5 No No
7 empty 1.67 69.3 11.2 No No
8 empty 1.81 73.4 19.4 No No
9 empty 2.3 59.9 10.2 No No
10 empty 1.94 76.8 7.1 No No
3IKU_E Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.66 74.5 45.6 Yes Yes
2 empty 2.46 57.3 17 No No
3 empty 2.01 61.6 23.5 No No
4 empty 2.27 63.3 20.1 No No
5 empty 2.15 63.9 16 No No
6 empty 1.95 62.9 18.6 No No
7 empty 1.95 60.6 18.3 No No
8 empty 2.42 73.2 14.3 No No
9 empty 2.51 60.2 19.5 No No
10 empty 2.37 67.4 15.3 No No
3IKU_G Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.51 75.1 45.5 Yes Yes
2 empty 2.42 57.5 17 No No
3 empty 2.04 61.6 26.5 No No
4 empty 2.34 69 19.5 No No
5 empty 2.26 67 15.9 No No
6 empty 2 65.5 19.5 No No
7 empty 1.99 60.9 18.3 No No
8 empty 2.67 67.8 23.6 No No
9 empty 2.34 69.3 14.2 No No
10 empty 2.47 61.6 18.7 No No
3IKY_B Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.53 68.4 47.2 Yes Yes
2 empty 2.2 59.4 28.3 No No
3 empty 2.3 68.4 27.8 No No
4 empty 2.08 63.7 20.1 No No
5 empty 2.32 69.6 17.2 No No
6 empty 2.27 72.1 14.2 No No
7 empty 2.03 66.6 12.3 No No
8 empty 2.58 57.5 13.9 No No
9 empty 2.63 58.8 16.1 No No
10 empty 2.11 53.8 12.3 No No
3IKU_C Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.61 74.7 45.7 Yes Yes
2 empty 2.46 54.9 18.1 No No
3 empty 2.04 62.5 26.9 No No
4 empty 2.03 61.1 19.2 No No
5 empty 2.23 65.2 16.2 No No
6 empty 1.99 67 18.5 No No
7 empty 2.47 75.1 15.8 No No
8 empty 2.35 70.5 11.6 No No
9 empty 2.46 62 17.3 No No
10 empty 2.19 61.2 13.8 No No
3IKY_J Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.54 69.8 43.9 Yes Yes
2 empty 2.22 60.2 27.6 No No
3 empty 2.35 67.3 21.4 No No
4 empty 2.33 70.5 12.2 No No
5 empty 2.16 67.5 16.6 No No
6 empty 2.24 69.8 15.1 No No
7 empty 2.7 60.4 15.3 No No
8 empty 2.62 57.8 14.3 No No
9 empty 2.43 65.1 15.8 No No
10 empty 2.01 55.2 12.5 No No
4A61_A Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.42 71.1 52.6 Yes Yes
2 empty 2.45 64 24.8 No No
3 empty 2.19 61.7 28.8 No No
4 empty 1.82 65 19.8 No No
5 empty 1.98 62.7 22.8 No No
6 empty 2.66 55.5 21 No No
7 empty 2.22 68.2 15.1 No No
8 empty 2.14 58.2 12.1 No No
9 empty 2.57 63.4 12.4 No No
10 empty 2.54 55.5 12.9 No No
2QU4_A Plasmid segregation protein ParM Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.47 64.9 48.2 Yes No
2 empty 2.42 63.8 32.3 No No
3 empty 2.24 59.7 25.4 No No
4 empty 2.26 64.6 24.4 No No
5 empty 1.95 63.7 19.9 No No
6 empty 2.03 65.9 12.4 No No
7 empty 2.68 64.1 13 No No
8 empty 2.55 64.1 15.1 No No
9 empty 2.17 46 14.3 No No
10 empty 2.51 51.2 11.7 No No
1MWM_B Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.52 74.7 45.4 Yes Yes
2 empty 2.59 54.9 25.1 No No
3 empty 2.05 60.6 27 No No
4 empty 2.29 63.3 19.7 No No
5 empty 1.88 63.9 18.7 No No
6 empty 2.44 69.5 14.9 No No
7 empty 1.96 64 18.6 No No
8 empty 2.5 73.5 11.7 No No
9 empty 2.45 61.5 17.2 No No
10 empty 2.15 58 16.7 No No
3IKY_L Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.54 68.7 44.5 Yes Yes
2 empty 2.25 60 24.9 No No
3 empty 2.42 66.4 19.9 No No
4 empty 1.93 69.6 18.8 No No
5 empty 2.34 69.9 13.2 No No
6 empty 2.15 64.6 15.2 No No
7 empty 2.58 61.2 12.8 No No
8 empty 2.32 68.9 13.9 No No
9 empty 2.78 57.8 12.7 No No
10 empty 2.54 61.8 15.1 No No
3IKU_K Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.67 74.5 46.3 Yes Yes
2 empty 2.41 53.2 17.4 No No
3 empty 2.06 61.2 23 No No
4 empty 2.59 67.3 27.2 No No
5 empty 2.1 64.9 15 No No
6 empty 2.01 63.8 18.7 No No
7 empty 1.99 64.1 18.3 No No
8 empty 2.35 69 14 No No
9 empty 2.47 68.6 16.7 No No
10 empty 2.16 54 11.4 No No
5AEY_C Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.26 78.2 35.2 Yes Yes
2 empty 2.25 62 24.6 No No
3 empty 2.43 70.2 22 No No
4 empty 1.81 66.7 17.3 No No
5 empty 2.38 69.4 24.7 No No
6 empty 2.23 61.5 13.8 No No
7 empty 1.91 60.1 13.8 No No
8 empty 2.21 63 18.9 No No
9 empty 2.1 71.1 14.2 No No
10 empty 2.85 60.8 18 No No
5AEY_E Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 77.2 36.5 Yes Yes
2 empty 2.31 62 24.5 No No
3 empty 1.76 64.6 17 No No
4 empty 2.27 68 21.4 No No
5 empty 2.31 66.6 12 No No
6 empty 1.87 63.2 14.2 No No
7 empty 1.98 59.6 15.9 No No
8 empty 2.07 67.4 14.1 No No
9 empty 2.22 64.5 18.3 No No
10 empty 2.68 61.4 21 No No
2ZGY_B Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.34 76 45.3 Yes Yes
2 empty 2.37 60.7 26.3 No No
3 empty 2.53 57.8 16.5 No No
4 empty 2.43 69.6 17.3 No No
5 empty 1.9 62.7 20.5 No No
6 empty 2.65 69.3 19.7 No No
7 empty 2.31 69.3 15.7 No No
8 empty 1.98 70.4 13.5 No No
9 empty 2.12 58.7 12.7 No No
10 empty 2.11 56.6 11.9 No No
3IKY_F Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.6 69.1 46 Yes Yes
2 empty 2.24 59.4 25.6 No No
3 empty 2.38 67.1 19.8 No No
4 empty 1.99 64.4 20.4 No No
5 empty 2.11 67.1 14.7 No No
6 empty 2.33 66.3 14.4 No No
7 empty 2.75 58.3 17.3 No No
8 empty 2.74 57.3 15.5 No No
9 empty 2.65 67.3 13.7 No No
10 empty 2.3 47.5 11.8 No No
3IKY_K Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.52 69 48.3 Yes Yes
2 empty 2.25 62.6 27.9 No No
3 empty 2.25 64.4 24.6 No No
4 empty 1.97 62.2 19.8 No No
5 empty 2.37 70 19.2 No No
6 empty 2.24 65 16.1 No No
7 empty 2.6 61.3 15 No No
8 empty 2.35 69.9 13.7 No No
9 empty 2.34 53.4 16.3 No No
10 empty 2.72 58.6 13.6 No No
3IKU_D Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.59 73.4 45.5 Yes Yes
2 empty 2.4 53.5 17.6 No No
3 empty 2.07 60.1 27.1 No No
4 empty 2.2 65.5 18.7 No No
5 empty 2.27 63.4 15 No No
6 empty 2.03 62.7 18.4 No No
7 empty 1.99 64.5 15.8 No No
8 empty 2.47 72.7 10.9 No No
9 empty 2.47 62.1 16.1 No No
10 empty 2.4 62.4 14.4 No No
3IKY_G Plasmid segregation protein ParM Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.53 68.8 47.9 Yes Yes
2 empty 2.2 59 25 No No
3 empty 2.4 66.6 22.8 No No
4 empty 2.06 62.5 24.6 No No
5 empty 2.29 77.3 12.9 No No
6 empty 2.03 66.9 12.5 No No
7 empty 2.09 63.7 21.1 No No
8 empty 2.29 53.3 16 No No
9 empty 2.38 71.7 13.4 No No
10 empty 2.58 57.5 14.7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed26
Domains assessed as druggable using the strict criteria7
Domains assessed as druggable using the relaxed criteria26

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1MWK_B (79579) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 2.3Å Yes No
1MWK_B (79578) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 2.3Å Yes No
1MWK_A (79577) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 2.3Å Yes No
1MWK_A (79576) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 2.3Å Yes No
1MWM_A (79580) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 1.99Å Yes No
1MWM_B (79583) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 1.99Å Yes No
1MWM_A (79581) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 1.99Å Yes No
1MWM_B (79582) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 1.99Å Yes No
2QU4_A (151365) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 16Å Yes No
2QU4_A (151366) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 16Å Yes No
2ZGY_A (4172989) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 (Homo Multimer) 1.9Å Yes Yes
2ZGY_B (154427) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 1.9Å Yes Yes
2ZGY_A (154426) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 1.9Å Yes No
2ZGY_A (154425) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 1.9Å Yes No
2ZGY_B (154428) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 1.9Å Yes No
2ZGY_B (4172989) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 (Homo Multimer) 1.9Å Yes Yes
2ZGZ_B (4094583) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 (Homo Multimer) 2.25Å Yes Yes
2ZGZ_B (154432) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 2.25Å Yes No
2ZGZ_B (154431) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 2.25Å Yes Yes
2ZGZ_A (154429) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 2.25Å Yes Yes
2ZGZ_A (154430) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 2.25Å Yes No
2ZGZ_A (4094583) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 (Homo Multimer) 2.25Å Yes Yes
2ZHC_A (154466) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 23Å Yes No
2ZHC_A (154467) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, Actin/HSP70 23Å Yes No
3IKU_A (3480079) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, UNMATCHED 18Å Yes No
3IKU_A (3480080) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, UNMATCHED 18Å Yes Yes
3IKY_A (3480084) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, UNMATCHED 18Å Yes No
3IKY_A (3480085) Plasmid segregation protein ParM Ribonuclease H-like motif, Actin-like ATPase domain, UNMATCHED 18Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score