Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EAPA (P11838) - Overview - Molecular Target Synopsis

Protein


EAPA, Endothiapepsin
Enzyme Classification 3.4.23.22
UniProt P11838

Also Known as CARP_CRYPA, EAPA, EPN-1


5OJE
ENDOTHIAPEPSIN WITH LIGAND VSK-B24
RCSB/PDB
Inspect Structure
See all 3D Structures for EAPA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
419P11838-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project EAPA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For EAPA there are:
532 structures (532 chains) solved
154 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

EAPA is solved in complex with the approved drug(s):

ROC/SAQUINAVIR (3PWW_A),
CFF/CAFFEINE (4Y4D_A),
RIT/RITONAVIR (3PRS_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


EAPA has been screened with 18 compounds (19 bioactivities). (see details)