Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

PSKH1 (P11801) - Overview - Molecular Target Synopsis


PSKH1, Serine/threonine-protein kinase H1
Enzyme Classification
UniProt P11801

Also Known as KPSH1_HUMAN, PSKH1

May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing. Homodimer.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: PSKH1 is active in the following subcellular-locations: cell membrane, centrosome, cytoplasm, cytoskeleton, endoplasmic reticulum membrane, golgi apparatus, microtubule organizing center, nucleus speckle.
GO terms: PSKH1 is active in the following subcellular-locations: endoplasmic reticulum membrane, Golgi apparatus, microtubule organizing center, nuclear speck, nucleoplasm, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project PSKH1 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: NCI_H322M, SNB_75, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SiHa, NCI-H1581, SK-MES-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HUVEC, IMR-90

(see details)

RNA Interference

PSKH1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB453, KPD. (see details)

3D Structures

At greater than 35% identity similarity to PSKH1 there are:
163 structures (250 chains) solved
125 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

PSKH1 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

PSKH1 has been screened with compounds ( bioactivities). (see details)