Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PSKH1 (P11801) - Overview - Molecular Target Synopsis

Protein


PSKH1, Serine/threonine-protein kinase H1
Enzyme Classification 2.7.11.1
UniProt P11801

Also Known as KPSH1_HUMAN, PSKH1

May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing. Homodimer.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
424ENSG00000159792ENST00000291041ENSP00000291041P11801-1

Sub-cellular localization


UniProt: PSKH1 is active in the following subcellular-locations: cell membrane, centrosome, cytoplasm, cytoskeleton, endoplasmic reticulum membrane, golgi apparatus, microtubule organizing center, nucleus speckle.
GO terms: PSKH1 is active in the following subcellular-locations: endoplasmic reticulum membrane, Golgi apparatus, microtubule organizing center, nuclear speck, nucleoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PSKH1 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, SNB_75, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SiHa, NCI-H1581, SK-MES-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HUVEC, IMR-90

(see details)

RNA Interference


PSKH1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB453, KPD. (see details)

3D Structures


At greater than 35% identity similarity to PSKH1 there are:
163 structures (250 chains) solved
125 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

PSKH1 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (2YAB_A, 2YAB_B, 4Y5Q_A),
DB8/BOSUTINIB (3SOA_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PSKH1 has been screened with compounds ( bioactivities). (see details)