Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Cyp17a1 (P11715) - Overview - Molecular Target Synopsis

Protein


Cyp17a1, Steroid 17-alpha-hydroxylase/17,20 lyase
Enzyme Classification 1.14.14.19
UniProt P11715

Also Known as CP17A_RAT, Cyp17a1, Cyp17

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
507P11715-1

Sub-cellular localization


UniProt: Cyp17a1 is active in the following subcellular-locations: membrane.
GO terms: Cyp17a1 is active in the following subcellular-locations: cell projection, endoplasmic reticulum, intracellular membrane-bounded organelle, membrane, neuronal cell body.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Cyp17a1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry


Cyp17a1 has been screened with 289 compounds (497 bioactivities), 125 compounds have bioactivities that show binding affinity of <= 500nM (152 bioactivities). (see details)