Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

Cyp17a1 (P11715) - Overview - Molecular Target Synopsis


Cyp17a1, Steroid 17-alpha-hydroxylase/17,20 lyase
Enzyme Classification
UniProt P11715

Also Known as CP17A_RAT, Cyp17a1, Cyp17

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: Cyp17a1 is active in the following subcellular-locations: membrane.
GO terms: Cyp17a1 is active in the following subcellular-locations: cell projection, endoplasmic reticulum, intracellular membrane-bounded organelle, membrane, neuronal cell body.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project Cyp17a1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry

Cyp17a1 has been screened with 289 compounds (497 bioactivities), 125 compounds have bioactivities that show binding affinity of <= 500nM (152 bioactivities). (see details)