VDR (P11473) - Overview - Molecular Target Synopsis
VDR, Vitamin D3 receptor
Also Known as VDR_HUMAN, VDR, NR1I1
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF. Interacts with SNW1. Interacts with IRX4, the interaction doesn't affect its transactivation activity.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|427||ENSG00000111424||ENST00000229022, ENST00000549336, ENST00000395324||ENSP00000449573, ENSP00000378734, ENSP00000229022||P11473-1|
|VDR is targeted by Approved Drugs Calcitriol, Cholecalciferol, Calcifediol, Calcipotriene, Ergocalciferol, Paricalcitol, Doxercalciferol. (see details)|
UniProt: VDR is active in the following subcellular-locations: Nucleus.
GO terms: VDR is active in the following subcellular-locations: nucleoplasm, nucleus, receptor complex, RNA polymerase II transcription factor complex.
|Please click the link to see mutations reported in COSMIC - Cell Lines Project|
|Please click the link to see mutations reported in COSMIC|
|Please click the link to see mutations reported in Cancer Gene Census|
|Please click the link to see mutations reported in ICGC|