Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NAT2 (P11245) - Overview - Molecular Target Synopsis

Protein


NAT2, Arylamine N-acetyltransferase 2
Enzyme Classification 2.3.1.5
UniProt P11245

Also Known as ARY2_HUMAN, NAT2, AAC2

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

2PFR
HUMAN N-ACETYLTRANSFERASE 2
RCSB/PDB
Inspect Structure
See all 3D Structures for NAT2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
292ENSG00000156006ENST00000286479ENSP00000286479
290P11245-1
178ENSG00000156006ENST00000520116ENSP00000428416

Sub-cellular localization


UniProt: NAT2 is active in the following subcellular-locations: cytoplasm.
GO terms: NAT2 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NAT2 has gain in 0 cell-lines, loss in 11 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_92, NCI_H460, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: GP2d, CW-2, IM-95m

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For NAT2 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NAT2 has been screened with 3 compounds (3 bioactivities). (see details)