CHRNB1 (P11230) - Overview - Molecular Target Synopsis
CHRNB1, Acetylcholine receptor subunit beta
Also Known as ACHB_HUMAN, CHRNB1, ACHRB, CHRNB
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (PubMed:15609996).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: CHRNB1 is active in the following subcellular-locations: cell junction, cell membrane, postsynaptic cell membrane, synapse.
GO terms: CHRNB1 is active in the following subcellular-locations: acetylcholine-gated channel complex, cell junction, integral component of plasma membrane, integral component of postsynaptic specialization membrane, neuromuscular junction, neuron projection, synapse.