Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CHRNB1 (P11230) - Overview - Molecular Target Synopsis

Protein


CHRNB1, Acetylcholine receptor subunit beta
UniProt P11230

Also Known as ACHB_HUMAN, CHRNB1, ACHRB, CHRNB

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (PubMed:15609996).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CHRNB1 is active in the following subcellular-locations: cell junction, cell membrane, postsynaptic cell membrane, synapse.
GO terms: CHRNB1 is active in the following subcellular-locations: acetylcholine-gated channel complex, cell junction, integral component of plasma membrane, integral component of postsynaptic specialization membrane, neuromuscular junction, neuron projection, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CHRNB1 has gain in 1 cell-lines, loss in 6 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_MB_231, SN12C, UO_31

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LXFL529, CAL-12T, EFM-192C

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, HMEC, SK-N-SH

(see details)

3D Structures


At greater than 50% identity similarity to CHRNB1 there are:
14 structures (19 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CHRNB1 has been screened with 287 compounds (439 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (8 bioactivities). (see details)