Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

UMPS (P11172) - Overview - Molecular Target Synopsis

Protein


UMPS, Uridine 5'-monophosphate synthase
Enzyme Classification 2.4.2.10
UniProt P11172

Also Known as UMPS_HUMAN, UMPS

Homodimer.

4HKP
CRYSTAL STRUCTURE OF HUMAN OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE COMPLEXED WITH CMP-N3-OXIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for UMPS

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: UMPS is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project UMPS has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_3, TK_10, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NIH:OVCAR-3, OvCA 432, NCI-H520

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, HSMM, MCF-7

(see details)

3D Structures


For UMPS there are:
38 structures (68 chains) solved
34 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


UMPS has been screened with 37 compounds (42 bioactivities), 19 compounds have bioactivities that show binding affinity of <= 500nM (20 bioactivities). (see details)