Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC2A3 (P11169) - Overview - Molecular Target Synopsis

Protein


SLC2A3, Solute carrier family 2, facilitated glucose transporter member 3
UniProt P11169

Also Known as GTR3_HUMAN, SLC2A3, GLUT3

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).

4ZW9
CRYSTAL STRUCTURE OF HUMAN GLUT3 BOUND TO D-GLUCOSE IN THE OUTWARD- OCCLUDED CONFORMATION AT 1.5 ANGSTROM
RCSB/PDB
Inspect Structure
See all 3D Structures for SLC2A3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC2A3 is active in the following subcellular-locations: cell membrane, cell projection, perikaryon.
GO terms: SLC2A3 is active in the following subcellular-locations: cell projection, extracellular exosome, ficolin-1-rich granule membrane, integral component of membrane, integral component of plasma membrane, perikaryon, plasma membrane, secretory granule membrane, specific granule membrane, tertiary granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC2A3 has gain in 6 cell-lines, loss in 2 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, NCI_H322M, HCT_15

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OUMS-23, MKN-74, SW 480

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, K562, SK-N-SH

(see details)

3D Structures


For SLC2A3 there are:
4 structures (6 chains) solved
4 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC2A3 is solved in complex with the approved drug(s):

BGC/DEXTROSE (4ZW9_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC2A3 has been screened with 60 compounds (61 bioactivities), 30 compounds have bioactivities that show binding affinity of <= 500nM (30 bioactivities). (see details)