Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC2A2 (P11168) - Overview - Molecular Target Synopsis

Protein


SLC2A2, Solute carrier family 2, facilitated glucose transporter member 2
UniProt P11168

Also Known as GTR2_HUMAN, SLC2A2, GLUT2

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC2A2 is active in the following subcellular-locations: membrane.
GO terms: SLC2A2 is active in the following subcellular-locations: apical plasma membrane, brush border, cell-cell junction, cytoplasm, integral component of plasma membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC2A2 has gain in 16 cell-lines, loss in 0 cell-lines and no signal in 989 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_MEL_5, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hep G2, C3A, HCC1534

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to SLC2A2 there are:
8 structures (10 chains) solved
8 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC2A2 is solved in complex with the approved drug(s):

BGC/DEXTROSE (4ZW9_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC2A2 has been screened with 59 compounds (60 bioactivities), 4 compounds have bioactivities that show binding affinity of <= 500nM (4 bioactivities). (see details)