Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC2A2 (P11168) - Overview - Molecular Target Synopsis


SLC2A2, Solute carrier family 2, facilitated glucose transporter member 2
UniProt P11168

Also Known as GTR2_HUMAN, SLC2A2, GLUT2

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: SLC2A2 is active in the following subcellular-locations: membrane.
GO terms: SLC2A2 is active in the following subcellular-locations: apical plasma membrane, brush border, cell-cell junction, cytoplasm, integral component of plasma membrane, membrane, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC2A2 has gain in 16 cell-lines, loss in 0 cell-lines and no signal in 989 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MCF7, SK_MEL_5, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hep G2, C3A, HCC1534

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 50% identity similarity to SLC2A2 there are:
8 structures (10 chains) solved
8 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC2A2 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

SLC2A2 has been screened with 59 compounds (60 bioactivities), 4 compounds have bioactivities that show binding affinity of <= 500nM (4 bioactivities). (see details)