Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LIPC (P11150) - Overview - Molecular Target Synopsis

Protein


LIPC, Hepatic triacylglycerol lipase
Enzyme Classification 3.1.1.3
UniProt P11150

Also Known as LIPC_HUMAN, LIPC, HTGL

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LIPC is active in the following subcellular-locations: secreted.
GO terms: LIPC is active in the following subcellular-locations: endoplasmic reticulum lumen, extracellular region, extracellular space, high-density lipoprotein particle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LIPC has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, CAKI_1, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCUM-1, SNU-5, HuH-7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to LIPC there are:
4 structures (12 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LIPC has been screened with 371 compounds (376 bioactivities), 282 compounds have bioactivities that show binding affinity of <= 500nM (286 bioactivities). (see details)