Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

P2 (P11124) - Overview - Molecular Target Synopsis

Protein


P2, RNA-directed RNA polymerase
Enzyme Classification 2.7.7.48
UniProt P11124

Also Known as RDRP_BPPH6, P2

Rna-dependent RNA polymerase part of the packaging complex that packages the viral RNA segments, replicate them into a double-stranded form and transcribe them. Part of the packaging complex composed of RDRP, P4 and P7. Interacts with P7.

5FJ6
STRUCTURE OF THE P2 POLYMERASE INSIDE IN VITRO ASSEMBLED BACTERIOPHAGE PHI6 POLYMERASE COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for P2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
665P11124-1

Sub-cellular localization


UniProt: P2 is active in the following subcellular-locations: virion.
GO terms: P2 is active in the following subcellular-locations: virion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project P2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For P2 there are:
26 structures (73 chains) solved
12 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis