Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACP2 (P11117) - Overview - Molecular Target Synopsis

Protein


ACP2, Lysosomal acid phosphatase
Enzyme Classification 3.1.3.2
UniProt P11117

Also Known as PPAL_HUMAN, ACP2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACP2 is active in the following subcellular-locations: lysosome lumen, lysosome membrane.
GO terms: ACP2 is active in the following subcellular-locations: extracellular exosome, integral component of membrane, lysosomal lumen, lysosomal membrane, lysosome, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACP2 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: EKVX, HT29, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1734, RERF-LC-KJ, A-673

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HUVEC, HeLa-S3

(see details)

3D Structures


At greater than 50% identity similarity to ACP2 there are:
6 structures (18 chains) solved
6 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

ACP2 is solved in complex with the approved drug(s):

TAR/TARTARIC ACID (1RPA_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACP2 has been screened with compounds ( bioactivities). (see details)