Molecular Target Synopsis
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PNMT (P11086) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed82
Chains with at least one site assessed as druggable using the strict criteria82
Chains with at least one site assessed as druggable using the relaxed criteria82


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2OBF_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.44 93.4 32.4 Yes Yes
2 empty 1.79 70.2 23.4 No No
3 empty 2.54 66.2 18.2 No No
4 empty 2.18 62.6 15 No No
5 empty 2.01 72.2 18.7 No No
6 empty 2.55 61.9 19.2 No No
7 empty 2.11 62.4 16 No No
8 empty 2.3 70.2 8.4 No No
9 empty 2.15 72 11.3 No No
10 empty 1.86 66.4 9.9 No No
3HCA_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.4 94.4 30.5 Yes Yes
2 empty 2.04 70.5 30.5 No No
3 empty 2.33 68.8 16.7 No No
4 empty 1.91 72.2 14.5 No No
5 empty 2.53 62 14.1 No No
6 empty 2.35 70 9.9 No No
7 empty 2 72.7 10.6 No No
8 empty 2.25 71.1 13.9 No No
9 empty 2.29 59.4 10.2 No No
10 empty 2.25 76.1 9.1 No No
2ONY_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.4 95 26.2 Yes Yes
2 empty 2.32 69.6 17.5 No No
3 empty 1.81 68.5 23.8 No No
4 empty 2.04 72.8 13.8 No No
5 empty 2.38 69.2 9.9 No No
6 empty 2.29 62.7 12.7 No No
7 empty 2.09 70.8 10.9 No No
8 empty 2.36 73.3 9 No No
9 empty 2.46 62.2 12.1 No No
10 empty 2.32 64 15.3 No No
3KR1_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 85.8 24.5 Yes Yes
2 empty 2.11 62.5 16.2 No No
3 empty 2.68 63.1 20.4 No No
4 empty 1.91 71.6 17.6 No No
5 empty 2.43 68.4 13.8 No No
6 empty 2.15 66.7 15 No No
7 bound 1.36 98.2 0 Yes No
8 empty 2.32 66.6 10.9 No No
9 empty 2.07 58.8 12.6 No No
10 empty 1.85 64 9.6 No No
2OPB_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.37 94.9 32.2 Yes Yes
2 empty 1.91 70 24.4 No No
3 empty 2.34 70.6 13.9 No No
4 empty 1.97 64.1 17.5 No No
5 empty 2.23 67.7 18.6 No No
6 empty 2.36 64.8 19.3 No No
7 empty 2.29 61.2 15.9 No No
8 empty 1.99 70.3 10.6 No No
9 empty 2.4 72.3 9.3 No No
10 empty 1.61 66.8 8.6 No No
3KQP_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 80.9 30.4 Yes Yes
2 empty 2.26 70.5 16.7 No No
3 empty 1.9 69.7 23.5 No No
4 empty 2.18 69.8 17.1 No No
5 bound 1.35 98.6 0 Yes No
6 empty 2.33 71.8 8.7 No No
7 empty 2.39 72.5 9.8 No No
8 empty 2.32 61.5 14.3 No No
9 empty 1.58 60.9 9 No No
10 empty 2.54 73.6 8.5 No No
2AN4_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.37 94.3 17.5 Yes Yes
2 empty 2.33 69.7 17.9 No No
3 empty 1.92 71 24.4 No No
4 empty 2.1 70.3 12.3 No No
5 empty 2.4 60.7 14.3 No No
6 empty 2.32 70.7 10.6 No No
7 empty 2.01 71.3 11.9 No No
8 empty 2.12 65.2 11.1 No No
9 empty 2.31 72.7 13.3 No No
10 empty 1.81 60.6 14.1 No No
3KQM_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 85.1 28.9 Yes Yes
2 empty 1.9 70.5 25.1 No No
3 empty 2.56 65.9 18.3 No No
4 empty 2.18 61.4 16.1 No No
5 empty 2.36 60 16.7 No No
6 empty 2.42 63 16.8 No No
7 empty 2.39 68.3 10.9 No No
8 empty 2.14 56.4 11.5 No No
9 empty 1.69 68.9 7.8 No No
10 empty 1.39 65.6 10.2 No No
4MQ4_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 89.5 28.5 Yes Yes
2 empty 2.58 66.6 19 No No
3 empty 2.11 61.6 14.4 No No
4 empty 1.77 70.4 16.2 No No
5 empty 2.48 63.7 17.1 No No
6 empty 2.15 64.8 13.1 No No
7 empty 2.28 72.2 12 No No
8 empty 2.25 64.5 11.8 No No
9 empty 1.76 67.7 8.6 No No
10 empty 2.52 75.7 8.7 No No
3KQW_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 84.6 30.6 Yes Yes
2 empty 2.7 61.4 18.7 No No
3 empty 1.95 71.5 11.7 No No
4 empty 2.39 67.2 16.7 No No
5 empty 2.19 61.3 16.5 No No
6 empty 2.22 68.6 11.2 No No
7 empty 2.19 60.9 11.1 No No
8 empty 1.71 61.8 9.3 No No
9 empty 1.73 68.8 9.5 No No
10 empty 2.11 65.1 15.5 No No
2AN3_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.72 63.9 25.5 Yes No
2 bound 1.53 98.4 0 Yes Yes
3 empty 2.18 63.3 14.7 No No
4 bound 1.4 98.2 0 Yes No
5 empty 1.94 67.9 17.1 No No
6 empty 2.31 68.7 13.1 No No
7 empty 2.6 63.2 10.7 No No
8 empty 2.28 73.7 10.5 No No
9 empty 1.7 64 8.4 No No
10 empty 1.86 63.8 11.3 No No
3HCA_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 87 24.3 Yes Yes
2 empty 2.1 61.5 16.9 No No
3 empty 2.73 60.6 21.3 No No
4 empty 1.93 72.5 16.6 No No
5 empty 2.39 68.3 16.3 No No
6 empty 2.06 71.5 12 No No
7 bound 1.38 97.7 0 Yes No
8 empty 2.18 65.8 11.9 No No
9 empty 2.35 74.3 12.6 No No
10 empty 2.1 63.9 19.2 No No
4MQ4_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.39 96.2 21.8 Yes Yes
2 empty 1.79 68.9 24 No No
3 empty 2.27 75.1 15.9 No No
4 empty 2.14 66.6 15.1 No No
5 empty 2.37 69.5 8.6 No No
6 empty 2.14 71.2 16.5 No No
7 empty 2.19 62 12.6 No No
8 empty 2.38 62.6 14.6 No No
9 empty 2.13 64.3 11.2 No No
10 empty 2.07 70.6 10.5 No No
1N7I_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.44 96.3 8 Yes Yes
2 empty 2.25 70 18.3 No No
3 empty 2 63.9 25.8 No No
4 empty 2.51 67.8 17.3 No No
5 empty 2.34 59.7 18.1 No No
6 empty 1.85 70.8 18 No No
7 empty 2.55 63.6 12.1 No No
8 empty 2.28 71.4 10.2 No No
9 empty 2 71.1 9.3 No No
10 empty 2.09 64.6 16.4 No No
2AN5_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.42 94.1 31.7 Yes Yes
2 empty 2.09 66.8 17.8 No No
3 bound 2.29 72.7 15.2 No No
4 empty 1.82 69.6 23 No No
5 empty 2.17 71.5 10.6 No No
6 empty 2.07 54.2 12.7 No No
7 empty 2.43 59.6 16.3 No No
8 empty 2.3 67.4 9.9 No No
9 empty 2.21 60.1 12.3 No No
10 empty 1.63 66 12 No No
2OBF_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.35 95 34.4 Yes Yes
2 empty 2.16 63.9 27.5 No No
3 empty 2.23 70.1 13.3 No No
4 empty 1.86 70.3 24.2 No No
5 empty 2.01 75.6 11.3 No No
6 empty 2.29 64.4 17.5 No No
7 empty 2 67.8 12.9 No No
8 empty 2.33 59.6 12.3 No No
9 empty 2.32 59 16.8 No No
10 empty 2.36 70.1 8.4 No No
2ONZ_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.37 95.9 32.6 Yes Yes
2 empty 1.97 70.5 30.8 No No
3 empty 2.31 69.2 17.1 No No
4 empty 1.88 72.6 15.4 No No
5 empty 2.28 71.1 10.9 No No
6 empty 2.42 60.2 17.1 No No
7 empty 2.4 69 11.9 No No
8 empty 1.95 59.3 10 No No
9 empty 2.2 64.4 12.9 No No
10 empty 2.22 58.8 10 No No
3KQQ_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 80.8 25.6 Yes Yes
2 empty 2.83 62.8 23.4 No No
3 empty 2.09 61.7 17.7 No No
4 empty 1.91 71.1 23.2 No No
5 bound 1.47 99 0 Yes No
6 empty 2.25 68.1 10.3 No No
7 empty 1.71 65.5 8.5 No No
8 empty 2.24 59.4 12.1 No No
9 empty 1.46 63.3 9.5 No No
10 empty 1.77 62.1 14.7 No No
3KQP_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.69 62.9 24.2 Yes No
2 bound 1.65 89.3 23.8 Yes Yes
3 empty 2.13 61.9 16.5 No No
4 empty 1.85 72.2 22.9 No No
5 bound 1.46 100 0 Yes No
6 empty 2.09 70.4 15.8 No No
7 empty 2.27 70.8 13.6 No No
8 empty 2.25 60.4 12.6 No No
9 empty 1.65 68.5 8.5 No No
10 empty 1.52 63.1 9.4 No No
2G8N_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.25 96.1 22.4 Yes Yes
2 empty 1.97 70.5 29.3 No No
3 empty 2.29 68.4 17.6 No No
4 empty 2.1 65.9 16.8 No No
5 empty 2.31 68.5 9.8 No No
6 empty 1.55 74 10.9 No No
7 empty 2.1 72.9 10.1 No No
8 empty 2.18 61.3 15.2 No No
9 empty 2.46 61.1 14.6 No No
10 empty 2.32 64.6 14.9 No No
3KQW_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.45 94.8 30.3 Yes Yes
2 empty 1.91 70.6 23.6 No No
3 empty 2.18 68.1 17.1 No No
4 empty 2.28 70.7 16.3 No No
5 empty 2.08 64.5 18.2 No No
6 empty 2.4 71.9 9.9 No No
7 empty 2.23 61.1 15.9 No No
8 empty 1.66 69.2 9.9 No No
9 empty 1.93 59.6 11.2 No No
10 empty 1.54 74.5 10 No No
2G70_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.41 91.3 32.5 Yes Yes
2 empty 2.18 70.3 30.9 No No
3 empty 1.92 63.2 17 No No
4 empty 2.49 65 26.6 No No
5 empty 2.44 68.1 15.5 No No
6 empty 2.19 68.4 15.6 No No
7 empty 2.28 66.4 12.6 No No
8 empty 2.38 64.1 13.2 No No
9 empty 2.56 69.7 10.6 No No
10 empty 2.18 70.6 12.3 No No
3KQT_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 93.1 31.9 Yes Yes
2 empty 2.26 67.7 17.7 No No
3 empty 2.19 69 18.2 No No
4 empty 1.75 68.7 24 No No
5 empty 2.15 62.8 14.4 No No
6 empty 2.35 69.7 10 No No
7 empty 2.45 62.5 11 No No
8 empty 2.25 61.2 14.6 No No
9 empty 1.58 61.7 11.2 No No
10 empty 1.61 70.5 10.6 No No
2AN5_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.73 62.3 24.9 Yes No
2 bound 1.44 99.3 0 Yes Yes
3 empty 2.16 63.1 15.2 No No
4 bound 1.44 98.3 0 Yes No
5 empty 2.26 69.9 11.6 No No
6 empty 1.81 71 11 No No
7 empty 1.76 69.5 8.6 No No
8 empty 2.23 61.9 14 No No
9 empty 2.07 60.8 9.1 No No
10 empty 1.61 73.3 7 No No
3KQS_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.52 93.9 28.9 Yes Yes
2 empty 2.03 70.9 31 No No
3 empty 2.38 69.5 17.5 No No
4 empty 2.24 67.2 16.9 No No
5 empty 2.34 72.4 10.5 No No
6 empty 2.42 64.2 12.1 No No
7 empty 2.3 75.3 8.5 No No
8 empty 1.71 67 10.9 No No
9 empty 2.36 61.2 14.3 No No
10 empty 1.57 76 10.6 No No
3KQV_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 87.9 32.8 Yes Yes
2 empty 2.75 62.7 24 No No
3 empty 2.16 60.5 15.9 No No
4 empty 2.02 72.4 14 No No
5 empty 2.34 69.1 12.4 No No
6 empty 2.1 65.3 19 No No
7 empty 1.61 61.2 10.1 No No
8 empty 1.73 66.3 8.3 No No
9 empty 2.02 58.5 9.8 No No
10 empty 1.94 74.1 10.5 No No
4DM3_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 94.3 29.3 Yes Yes
2 empty 2.1 64.1 18 No No
3 empty 2.35 69.9 14.8 No No
4 empty 1.75 68.9 23.6 No No
5 empty 2.18 69.7 16.5 No No
6 empty 2.38 67.8 9.5 No No
7 empty 2.3 61.7 14.9 No No
8 empty 2.3 62.3 17.1 No No
9 empty 1.84 62.2 9.4 No No
10 empty 1.51 73.7 10.7 No No
2ONZ_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 86 24.3 Yes Yes
2 bound 1.24 98.2 0 Yes Yes
3 empty 2.38 67.5 14.9 No No
4 empty 2.14 70.6 17.3 No No
5 empty 2.8 61.8 19 No No
6 empty 1.67 67.3 14.3 No No
7 empty 2.08 65.4 12.5 No No
8 empty 2.37 60.3 13.6 No No
9 empty 2.29 65.7 10.4 No No
10 empty 1.82 72.7 9.9 No No
3KR0_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 81.4 24.5 Yes Yes
2 empty 2.57 64 23.8 No No
3 empty 2.17 60.8 16.2 No No
4 empty 1.91 73 14.8 No No
5 bound 1.41 97.6 0 Yes No
6 empty 2.27 65.9 10.7 No No
7 empty 1.79 65.4 8.1 No No
8 empty 2.02 62.1 9.1 No No
9 empty 2.5 72.6 9.1 No No
10 empty 1.94 64.1 14.5 No No
2G71_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.79 63.7 24 Yes No
2 bound 1.46 99.8 0 Yes Yes
3 empty 2.05 61 16.9 No No
4 empty 1.94 70.6 24.4 No No
5 empty 2.03 65.9 13.6 No No
6 bound 1.41 98 0 Yes No
7 empty 2.17 69.1 13.7 No No
8 empty 2.08 67 13.4 No No
9 empty 1.78 69.8 8.1 No No
10 empty 1.7 61.6 10 No No
3KQM_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.38 94.9 9.3 Yes Yes
2 empty 2.22 68.5 17.3 No No
3 empty 1.91 68.7 25.1 No No
4 empty 2.26 69.8 15.7 No No
5 empty 2.39 71 9.2 No No
6 empty 2.18 74.4 9.6 No No
7 empty 2.24 62.6 12.1 No No
8 empty 1.51 73.9 9.8 No No
9 empty 2.3 61.6 13 No No
10 empty 1.82 59.2 12.7 No No
3KR1_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 94.4 25.5 Yes Yes
2 empty 2.34 69.6 18.6 No No
3 empty 1.89 69.8 25.1 No No
4 empty 2.16 69 15.1 No No
5 empty 2.15 67.8 17.7 No No
6 empty 1.98 71.4 16.5 No No
7 empty 2.31 63.8 15.2 No No
8 empty 2.36 70 9.2 No No
9 empty 1.86 62.7 10 No No
10 empty 1.96 56.8 11.4 No No
3KPV_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 77.6 25.8 Yes Yes
2 empty 2.13 60.8 15.8 No No
3 empty 1.79 69.6 16.6 No No
4 empty 2.37 66.6 14.8 No No
5 bound 1.42 99.7 0 Yes No
6 empty 2.53 62.6 18.7 No No
7 empty 2.36 67.7 10.9 No No
8 empty 2.14 59.8 11.5 No No
9 empty 1.57 65.4 8.6 No No
10 empty 2.22 61 14.7 No No
3KQY_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 86.8 24.5 Yes Yes
2 empty 2.16 63 15.8 No No
3 empty 2.37 66.3 18.4 No No
4 empty 2.57 59.5 18.9 No No
5 empty 1.91 71.4 23.6 No No
6 empty 2 68.6 17.1 No No
7 bound 1.45 98.4 0 Yes No
8 empty 2.2 65.9 9.8 No No
9 empty 2.27 59.9 11.5 No No
10 empty 2.54 73.7 9.8 No No
3HCB_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.35 98.6 0 Yes Yes
2 empty 2.07 70.9 28.1 No No
3 empty 2.3 69.8 15.3 No No
4 empty 2.16 63 21.8 No No
5 empty 2.37 70.9 10 No No
6 empty 2.07 69.7 14 No No
7 empty 2.47 58.8 15.8 No No
8 empty 2.32 62.7 15.2 No No
9 bound 1.62 83.6 11.9 No No
10 empty 2.21 61.3 10.6 No No
2OPB_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.29 98.9 0 Yes Yes
2 empty 2.52 65.4 22.7 No No
3 empty 2.22 61.4 16.9 No No
4 empty 1.75 73.1 14.8 No No
5 empty 2.13 68.7 14.1 No No
6 empty 1.75 67 8.6 No No
7 empty 2.35 73 8.6 No No
8 empty 1.76 64.1 8.7 No No
9 empty 2.29 63.5 11.3 No No
10 empty 2.12 70.5 11.1 No No
2AN4_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 82.9 24.2 Yes Yes
2 empty 2.6 62.1 27.8 No No
3 empty 2.19 63.8 16.9 No No
4 empty 2.28 68 13.6 No No
5 empty 1.97 67.5 16.4 No No
6 bound 1.39 98.9 0 Yes No
7 empty 1.69 67.6 9.2 No No
8 empty 2.03 59.4 10.3 No No
9 empty 1.75 62.2 8.6 No No
10 empty 2.07 63.6 12.6 No No
3KR2_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.6 63.6 24 Yes No
2 bound 1.58 87.8 24.5 Yes Yes
3 empty 2.15 63.4 15.7 No No
4 empty 2.02 70.1 20.9 No No
5 empty 2.04 70.6 13.1 No No
6 bound 1.35 98 0 Yes No
7 empty 2.21 66.6 9.6 No No
8 empty 2.17 59 11.6 No No
9 empty 1.62 61.2 10.6 No No
10 empty 1.72 67.4 8.4 No No
2G72_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.29 94.9 28.5 Yes Yes
2 empty 1.98 66.9 31 No No
3 empty 2.29 68.6 19.6 No No
4 empty 2.27 67.7 18.8 No No
5 empty 2.34 56.1 14.6 No No
6 empty 2.35 72.3 9.8 No No
7 empty 2.41 61.6 11.9 No No
8 empty 2.05 69.9 11.4 No No
9 empty 2.13 70.6 11.5 No No
10 empty 2.34 63.9 12.6 No No
3KPY_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 88.5 31.1 Yes Yes
2 empty 2.77 64.1 22.5 No No
3 empty 1.94 70.6 23.2 No No
4 empty 2.13 61.4 16.1 No No
5 empty 2.25 69.9 11.8 No No
6 empty 1.65 63.7 10.2 No No
7 empty 1.99 63.6 15.3 No No
8 empty 1.72 68.9 8 No No
9 empty 1.97 74.5 10.5 No No
10 empty 2.09 62 9.7 No No
3HCE_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 90.5 30.2 Yes Yes
2 empty 2.69 62.4 26.2 No No
3 empty 2.1 68.6 15.5 No No
4 empty 2.17 64.7 15 No No
5 empty 2.39 68.5 21.2 No No
6 empty 1.96 67.4 20 No No
7 empty 2.23 68.8 13 No No
8 empty 2.35 59.5 16.4 No No
9 empty 2.06 65.5 9.8 No No
10 empty 1.81 66.3 6.9 No No
2G71_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.5 85.5 37.1 Yes Yes
2 empty 2.11 70.2 31 No No
3 empty 2.35 71 15.2 No No
4 empty 2.33 73.6 9.6 No No
5 empty 2.13 69.7 14.5 No No
6 empty 1.63 73.9 10.9 No No
7 empty 2.39 61.8 13.6 No No
8 empty 2.03 63.8 9.5 No No
9 empty 2.33 60.5 13 No No
10 empty 2.44 73.5 9.9 No No
3KR0_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 93.6 32.3 Yes Yes
2 empty 2.34 70.4 15.7 No No
3 empty 2.18 67.4 17.2 No No
4 empty 1.7 71.5 18.2 No No
5 empty 2.33 59.7 22.8 No No
6 empty 2.35 69.9 9.3 No No
7 empty 1.88 73.2 13.8 No No
8 empty 2.27 62.8 14.7 No No
9 empty 2.25 77.4 9.1 No No
10 empty 2.23 59.7 15.4 No No
2G8N_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 67.3 30.3 Yes No
2 bound 1.21 99.5 0 Yes Yes
3 bound 1.39 98.3 0 Yes No
4 empty 2.04 63.3 15 No No
5 empty 2.41 66.1 16.3 No No
6 empty 2.68 60.4 18.8 No No
7 empty 2.32 69 11 No No
8 empty 2.2 60.3 14.3 No No
9 empty 2.19 62.3 18.7 No No
10 empty 1.96 71.4 11.3 No No
3HCE_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.45 93.9 31.7 Yes Yes
2 empty 2.35 68.9 17.6 No No
3 empty 2.22 69.5 18.1 No No
4 empty 2.06 62.9 19.4 No No
5 empty 1.89 72.3 19.2 No No
6 empty 1.68 72.8 18.7 No No
7 empty 2.38 73.5 9.8 No No
8 empty 2.66 60.4 14.7 No No
9 empty 1.91 57.4 10.6 No No
10 empty 2.54 77 7.4 No No
3HCB_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 88.5 23.8 Yes Yes
2 empty 2.13 61.9 14.7 No No
3 empty 2.38 67.5 14.7 No No
4 empty 1.98 70.5 23.6 No No
5 empty 2.72 60.1 17.3 No No
6 bound 1.44 97.2 0 Yes No
7 empty 2.17 67.4 12.1 No No
8 empty 2.23 70.1 10.9 No No
9 empty 1.73 67 8.4 No No
10 empty 2.22 57.2 11.8 No No
4MIK_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 89.3 27.3 Yes Yes
2 empty 2.56 66 22.4 No No
3 empty 2.1 63.5 14.4 No No
4 empty 1.96 71.1 16.4 No No
5 empty 2.21 70.9 12.5 No No
6 empty 2.08 66 17.7 No No
7 empty 1.72 69.7 8.5 No No
8 empty 2.11 57 12.1 No No
9 empty 2.45 73 9.6 No No
10 empty 2.25 68.6 7.9 No No
1HNN_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.38 83.1 25.8 Yes Yes
2 empty 2.29 65 13.1 No No
3 empty 2.16 67.7 12.7 No No
4 empty 2.06 64.9 14.4 No No
5 empty 1.93 74.8 13.8 No No
6 empty 2 66.3 18 No No
7 bound 1.39 99.3 0 Yes No
8 empty 1.73 67.6 16.1 No No
9 empty 2.15 65.4 12.7 No No
10 empty 2.73 63.7 15.3 No No
3KPV_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.34 95.1 28.7 Yes Yes
2 empty 1.78 69.9 23.6 No No
3 empty 2.31 70.1 17 No No
4 empty 2.18 68.6 15.9 No No
5 empty 2.35 63.4 11.1 No No
6 empty 2.42 70.5 10.5 No No
7 empty 2.31 62.1 14.7 No No
8 empty 2.08 75 8.3 No No
9 empty 2.23 55.4 11 No No
10 empty 1.59 66.4 9.4 No No
2G72_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 93.4 26.6 Yes Yes
2 empty 1.98 67.6 22.5 No No
3 bound 1.26 98.1 0 Yes No
4 empty 2.1 60.5 15.7 No No
5 empty 2.59 59.7 18.9 No No
6 empty 2.37 65.3 18.6 No No
7 empty 1.99 61.1 15.5 No No
8 empty 2.32 70.2 10.5 No No
9 empty 2.14 64.6 19.5 No No
10 empty 2.44 67.6 8.3 No No
3KQT_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 88.6 28.3 Yes Yes
2 empty 1.93 69.5 25.7 No No
3 empty 2.13 62 16.7 No No
4 empty 2.59 65.1 19.2 No No
5 empty 2.4 60.5 18.4 No No
6 empty 2.2 64.1 13.2 No No
7 empty 2.1 57.6 10.8 No No
8 empty 1.88 63.9 10.2 No No
9 empty 1.95 65.6 12.2 No No
10 empty 2.15 75 10.7 No No
3KQY_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.42 94.7 23.4 Yes Yes
2 empty 2.38 70.5 17.2 No No
3 empty 2.22 67.2 17 No No
4 empty 1.73 70.3 23.5 No No
5 empty 2.19 69 16.9 No No
6 empty 2.36 72.2 9.8 No No
7 empty 2.38 63.4 11.6 No No
8 empty 1.88 63.8 9.9 No No
9 empty 2.33 59.2 15 No No
10 empty 2.26 64.5 11.1 No No
3HCF_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.41 93.8 32 Yes Yes
2 empty 1.96 70.1 27.5 No No
3 empty 2.2 69.4 15.8 No No
4 empty 2.3 70.4 11.5 No No
5 empty 2.3 72.4 10 No No
6 empty 2.14 67.2 11.8 No No
7 empty 2.22 68.1 15.1 No No
8 empty 2.43 61 14 No No
9 empty 2.27 61.1 18.5 No No
10 empty 2.45 58.8 14.6 No No
3KR2_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.46 94.2 29.9 Yes Yes
2 empty 2.38 70.1 15.1 No No
3 empty 2.28 67.2 17.7 No No
4 empty 1.79 69.7 23.8 No No
5 empty 2.08 67 18.3 No No
6 empty 2.37 72.8 10.6 No No
7 empty 2.4 63.4 15.9 No No
8 empty 2.33 61.7 12.3 No No
9 empty 1.62 64.4 8.9 No No
10 empty 2.25 67.3 10.7 No No
3HCF_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.57 63.6 23.3 No No
2 bound 1.61 86.1 24.5 Yes Yes
3 empty 2.25 63.8 15.9 No No
4 empty 2.07 69.4 13.2 No No
5 bound 1.43 98.9 0 Yes No
6 empty 1.7 70.1 11.4 No No
7 empty 2.18 61.2 11.5 No No
8 empty 2.31 71.3 9.3 No No
9 empty 1.86 64.9 9.5 No No
10 empty 2.12 61.8 16.3 No No
3KQQ_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.45 94.4 31.2 Yes Yes
2 empty 2.3 70 16.4 No No
3 empty 1.77 69.7 22.7 No No
4 empty 2.16 70 15.9 No No
5 empty 2.11 69.7 11 No No
6 empty 2.34 62.2 17.6 No No
7 empty 2.35 72.3 9.1 No No
8 empty 2.44 59.6 11.4 No No
9 empty 2.06 71.6 13.7 No No
10 empty 2.32 61.2 14.9 No No
3KQO_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 83.7 30.4 Yes Yes
2 empty 2.77 63.6 23.9 No No
3 empty 2.15 61.7 16.7 No No
4 empty 1.6 73.4 18.1 No No
5 empty 2.28 67.9 14 No No
6 empty 2.19 57.3 12.6 No No
7 empty 1.69 62.9 10.9 No No
8 empty 2.4 60.4 15.4 No No
9 empty 1.66 67.5 9.5 No No
10 empty 2.03 72.3 10.5 No No
3KPY_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.52 82.2 35.9 Yes Yes
2 empty 2.27 71 16.6 No No
3 empty 1.86 70.6 22 No No
4 empty 2.12 69.5 17.3 No No
5 empty 2.39 69.4 9.9 No No
6 empty 2.29 65.5 11.4 No No
7 empty 1.63 63 8.5 No No
8 empty 1.79 57 14.1 No No
9 empty 2.34 62.8 14.6 No No
10 empty 2.46 65.3 13.9 No No
3KQO_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 94.6 13.2 Yes Yes
2 empty 1.89 69.3 25.1 No No
3 empty 2.27 67.5 16.8 No No
4 empty 2.09 70.4 10.6 No No
5 empty 2.35 70.6 8.8 No No
6 empty 2.25 60.7 10.8 No No
7 empty 1.78 58.2 12.5 No No
8 empty 2.33 63.5 14.7 No No
9 empty 1.69 69.4 9.6 No No
10 empty 1.67 74.1 10.3 No No
2G70_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 88.2 34.3 Yes Yes
2 empty 2.06 69.1 30.2 No No
3 empty 2.38 67.7 16.9 No No
4 empty 2.37 58.5 13.8 No No
5 empty 2.27 71.4 9.2 No No
6 empty 2.45 66.4 14.1 No No
7 empty 1.97 70.9 11 No No
8 empty 2 58.1 10.1 No No
9 empty 2.4 63.4 13.9 No No
10 empty 2.27 61.9 13 No No
3HCC_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.31 94.9 29.1 Yes Yes
2 empty 2.35 71.1 16.7 No No
3 empty 1.92 66.3 24.1 No No
4 empty 2.28 68.3 12 No No
5 empty 2.29 69 12.1 No No
6 empty 2.18 70 11 No No
7 empty 2.03 71.9 10.4 No No
8 empty 2.23 65.3 9.5 No No
9 empty 2.46 61.6 14 No No
10 empty 2.36 60.5 13.3 No No
1YZ3_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 85.6 27.7 Yes Yes
2 empty 1.92 68.6 30.3 No No
3 empty 2.03 65.5 16.6 No No
4 empty 2.41 65.7 12.2 No No
5 bound 1.43 96.8 0 Yes No
6 empty 2.02 65.7 12.4 No No
7 empty 2.22 67.1 15.8 No No
8 empty 2.57 61.4 19.9 No No
9 empty 2.03 69.2 11.2 No No
10 empty 2.24 60.1 16.2 No No
1N7J_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 95.9 12.7 Yes Yes
2 empty 2.1 62.1 19.2 No No
3 empty 2.21 72.6 14 No No
4 empty 1.76 69.1 17.1 No No
5 empty 2.24 59.1 17.8 No No
6 empty 2.33 72 10.2 No No
7 empty 1.52 73.1 11.9 No No
8 empty 2.25 66.9 14.5 No No
9 empty 2.38 61.8 11.9 No No
10 empty 2.28 80.3 9 No No
3KPJ_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.31 98.8 0 Yes Yes
2 bound 1.89 71.6 20 No No
3 empty 2.28 71 17.5 No No
4 empty 2.04 71 22.7 No No
5 empty 2.2 68.3 15.8 No No
6 empty 2.37 71.7 10.5 No No
7 empty 2.26 62.3 15.6 No No
8 empty 1.79 57.6 12.5 No No
9 empty 1.68 62 10.2 No No
10 empty 2.1 57.1 11.8 No No
3KPW_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 91.6 8.9 Yes Yes
2 empty 2.32 68.7 17.5 No No
3 empty 1.79 70.9 23.5 No No
4 empty 2.25 69.7 15.3 No No
5 bound 1.34 98.2 0 Yes No
6 empty 2.42 61.3 16.6 No No
7 empty 2.29 61.1 15.9 No No
8 empty 2.42 71.3 9.1 No No
9 empty 2.09 66.9 11.7 No No
10 empty 1.42 66 8.9 No No
4MIK_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.52 94.9 15.9 Yes Yes
2 empty 2.03 69.5 30.9 No No
3 empty 2.34 70.7 15.8 No No
4 empty 2.09 74.1 13.9 No No
5 empty 2.41 60.1 14.5 No No
6 empty 1.99 72.8 11.6 No No
7 empty 2.38 68.3 12.1 No No
8 empty 1.8 64.4 9.7 No No
9 empty 1.87 60.1 14.2 No No
10 empty 2.38 70.9 10.3 No No
3KPW_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 80.4 25.8 Yes Yes
2 empty 2.8 64.1 24.3 No No
3 empty 1.92 71.5 17.8 No No
4 empty 2.11 61 17.4 No No
5 bound 1.31 99.7 0 Yes No
6 empty 2.37 63.9 17.8 No No
7 empty 2.24 70 9.9 No No
8 empty 1.71 69 8.7 No No
9 empty 1.59 66.8 10.2 No No
10 empty 2.06 61.3 8.1 No No
1N7I_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.38 99.8 0 Yes Yes
2 empty 2.27 63.8 17.7 No No
3 empty 2.13 64.5 19.2 No No
4 empty 2.17 67.1 19.7 No No
5 empty 1.87 78.2 14.3 No No
6 empty 2.07 66 14.9 No No
7 empty 2.41 65.4 18.9 No No
8 bound 1.32 99.3 0 Yes No
9 empty 2.05 62.4 12.2 No No
10 empty 1.64 67.7 15.5 No No
1N7J_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.4 99.5 0 Yes Yes
2 empty 2.48 63.7 19.6 No No
3 empty 1.94 64.7 15.9 No No
4 empty 1.99 65.7 17.3 No No
5 empty 1.84 76.4 14.5 No No
6 bound 1.39 98.8 0 Yes No
7 empty 2.08 64.1 14.2 No No
8 empty 2.11 59.2 13.7 No No
9 empty 2.28 69.5 12.5 No No
10 empty 1.55 70.2 7.7 No No
2AN3_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.35 94.9 10.8 Yes Yes
2 empty 2.35 64.5 26.5 No No
3 empty 2.36 70.8 14.9 No No
4 empty 1.74 68.9 14.7 No No
5 empty 2.02 67.8 15.9 No No
6 empty 2.31 72 8.1 No No
7 empty 2.15 71.1 10.9 No No
8 empty 1.69 70.8 9.7 No No
9 empty 2.27 62.2 12.5 No No
10 empty 2.2 69.6 11.8 No No
1HNN_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 64.1 29.3 Yes No
2 bound 1.56 96.2 8 Yes Yes
3 empty 2.31 71.5 15.2 No No
4 empty 2.54 69.9 18 No No
5 empty 2.41 69.5 10.5 No No
6 empty 2.11 68.4 14.3 No No
7 empty 1.71 68.2 11.7 No No
8 empty 1.49 65 9.7 No No
9 empty 2.2 63 11 No No
10 empty 2.18 69.8 14 No No
3HCD_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.31 95.3 29.4 Yes Yes
2 empty 2.32 70.7 17.7 No No
3 empty 1.73 69.9 24.4 No No
4 empty 2.15 68.8 16 No No
5 empty 2.01 70 18.3 No No
6 empty 2.54 60.2 20.4 No No
7 empty 2.3 70.3 13.4 No No
8 empty 2.1 70.6 14.7 No No
9 empty 2.19 67.6 11.6 No No
10 empty 2.25 70.4 13.1 No No
1YZ3_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.45 88.3 35.5 Yes Yes
2 empty 1.97 70.1 30.5 No No
3 empty 2.3 70.4 17.5 No No
4 empty 1.68 71.4 15.5 No No
5 empty 2.25 72.5 9.3 No No
6 empty 2.05 72.6 12.8 No No
7 empty 2.36 63.2 14.7 No No
8 empty 2 55.8 12 No No
9 empty 2.33 52 12.2 No No
10 empty 2.31 65.9 10.6 No No
3KPU_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 79.9 25.6 Yes Yes
2 empty 1.85 68.8 32 No No
3 empty 2.16 64.6 15 No No
4 empty 2.4 67.7 18.5 No No
5 empty 2.52 61.9 17.1 No No
6 bound 1.38 98.7 0 Yes No
7 empty 2.39 68.4 11.2 No No
8 empty 1.47 64.1 10.1 No No
9 empty 1.9 73 10.2 No No
10 empty 1.88 63.2 15.9 No No
3KPJ_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.44 98.6 0 Yes Yes
2 empty 2.55 63.7 24 No No
3 empty 2.19 60.8 17.2 No No
4 empty 1.98 72.3 13.6 No No
5 empty 1.71 72.4 16.3 No No
6 empty 2.18 69.1 10.5 No No
7 empty 2.24 58.6 11.8 No No
8 empty 1.66 64.6 8.8 No No
9 empty 2.19 67.9 12.1 No No
10 empty 1.71 67.8 7.6 No No
3KQS_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 89 29.1 Yes Yes
2 empty 2.73 64 25.8 No No
3 empty 2.16 60.6 16.7 No No
4 empty 1.98 69.2 19.8 No No
5 empty 2.32 69.4 10.6 No No
6 empty 2.1 59.9 12.7 No No
7 empty 1.76 63.6 10.4 No No
8 empty 2.16 69.5 11.2 No No
9 empty 1.71 67.9 8.7 No No
10 empty 2.07 64.6 16.2 No No
4DM3_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 76.7 26.4 Yes Yes
2 empty 2.15 64.2 15.9 No No
3 empty 2.36 64.5 19.6 No No
4 empty 1.91 71.5 16.1 No No
5 empty 2.57 59.2 19.1 No No
6 bound 1.37 98.3 0 Yes No
7 empty 2.33 69.9 12.6 No No
8 empty 1.83 64.1 10.2 No No
9 empty 2.09 58.5 15.7 No No
10 empty 1.69 69.8 9 No No
3KQV_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 94 28.5 Yes Yes
2 empty 2.32 70.2 17.4 No No
3 empty 1.71 70.7 23.2 No No
4 empty 2.24 69.3 17.8 No No
5 empty 2.38 72.9 9.8 No No
6 empty 2.32 61.5 15.2 No No
7 empty 2.36 60.4 11.8 No No
8 empty 2.27 71.6 8.6 No No
9 empty 1.69 64.2 13.7 No No
10 empty 1.58 75.3 10.6 No No
3HCD_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.81 65.1 25.9 Yes No
2 bound 1.5 99.6 0 Yes Yes
3 empty 2.16 63.3 15.5 No No
4 empty 2.02 68.5 12.1 No No
5 empty 2.01 71.4 14.7 No No
6 bound 1.38 99.3 0 Yes No
7 empty 2.19 68 13.2 No No
8 empty 2.21 74.9 13.2 No No
9 empty 2.13 65 18.9 No No
10 empty 1.74 67.5 8.5 No No
2ONY_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 68.9 29.9 Yes No
2 bound 1.64 86.6 24.4 Yes Yes
3 bound 1.28 99.2 0 Yes No
4 empty 2.38 69.3 13.4 No No
5 empty 2.11 62.3 16 No No
6 empty 2.23 68.8 18.4 No No
7 empty 2.38 59.9 15.6 No No
8 empty 2.3 67.1 12.6 No No
9 empty 2.15 62.1 12.8 No No
10 empty 1.74 67.1 10.1 No No
3KPU_B Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.46 94.7 31.6 Yes Yes
2 empty 1.79 71.1 23 No No
3 empty 2.31 70.4 17.5 No No
4 empty 2.17 67.7 16.6 No No
5 empty 2.17 71.1 9.5 No No
6 empty 2.4 71.6 9.2 No No
7 empty 2.36 64.2 12 No No
8 empty 2.35 60.2 11.8 No No
9 empty 1.81 60.4 12.3 No No
10 empty 1.64 62 14 No No
3HCC_A Phenylethanolamine N-methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.7 63.5 23.5 No No
2 bound 1.53 98.4 0 Yes Yes
3 empty 2.22 68.1 18.2 No No
4 empty 1.9 68.7 21.5 No No
5 bound 1.48 98 0 Yes No
6 empty 1.99 64.6 12.2 No No
7 empty 2.06 69.4 10.7 No No
8 empty 2.45 61.2 11.2 No No
9 empty 2.28 67.7 10.7 No No
10 empty 1.76 68.8 8.9 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed61
Domains assessed as druggable using the strict criteria52
Domains assessed as druggable using the relaxed criteria61

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1HNN_A (65895) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.3Å Yes Yes
1HNN_B (65896) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.3Å Yes Yes
1N7I_A (91694) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.8Å Yes Yes
1N7I_B (91695) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.8Å Yes Yes
1N7J_A (91696) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.7Å Yes Yes
1N7J_B (91697) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.7Å Yes Yes
1YZ3_B (124269) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.4Å Yes Yes
1YZ3_A (4016903) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
1YZ3_B (4016903) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
1YZ3_A (124268) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.4Å Yes Yes
2AN3_B (127028) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.2Å Yes Yes
2AN3_A (4149465) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.2Å Yes Yes
2AN3_B (4149465) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.2Å Yes Yes
2AN3_A (127027) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.2Å Yes Yes
2AN4_B (127030) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.2Å Yes Yes
2AN4_A (127029) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.2Å Yes Yes
2AN4_A (4125365) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.2Å Yes No
2AN4_B (4125365) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.2Å Yes No
2AN5_A (127031) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.5Å Yes Yes
2AN5_B (127032) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.5Å Yes Yes
2G70_A (4257087) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
2G70_B (4257087) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
2G70_A (134720) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.4Å Yes Yes
2G70_B (134721) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.4Å Yes Yes
2G71_A (134722) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.2Å Yes Yes
2G71_B (134723) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.2Å Yes Yes
2G71_B (4152448) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.2Å Yes No
2G71_A (4152448) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.2Å Yes No
2G72_A (134724) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2Å Yes Yes
2G72_B (134725) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2Å Yes Yes
2G72_A (4171330) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2Å Yes Yes
2G72_B (4171330) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2Å Yes Yes
2G8N_A (134777) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.15Å Yes Yes
2G8N_B (134778) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.15Å Yes Yes
2G8N_A (4080227) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.15Å Yes Yes
2G8N_B (4080227) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.15Å Yes Yes
2OBF_A (3160374) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.3Å Yes Yes
2OBF_B (4018870) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.3Å Yes No
2OBF_A (4018870) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.3Å Yes No
2ONY_A (148915) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.6Å Yes Yes
2ONY_A (4170776) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.6Å Yes Yes
2ONY_B (4170776) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.6Å Yes Yes
2ONY_B (148916) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.6Å Yes Yes
2ONZ_A (3160842) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.8Å Yes Yes
2ONZ_B (4077038) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.8Å Yes Yes
2ONZ_A (4077038) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.8Å Yes Yes
2OPB_A (3160873) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase 2.8Å Yes Yes
2OPB_A (4011308) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.8Å Yes Yes
2OPB_B (4011308) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.8Å Yes Yes
3HCA_A (4131224) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes No
3HCA_B (4131224) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes No
3HCB_B (4187138) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
3HCB_A (4187138) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
3HCC_A (4077429) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.3Å Yes Yes
3HCC_B (4077429) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.3Å Yes Yes
3HCD_B (4060751) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.39Å Yes Yes
3HCD_A (4060751) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.39Å Yes Yes
3HCE_A (4064581) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.85Å Yes No
3HCE_B (4064581) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.85Å Yes No
3HCF_B (4010897) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.7Å Yes Yes
3HCF_A (4010897) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.7Å Yes Yes
3KPJ_A (4190450) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.5Å Yes Yes
3KPJ_B (4190450) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.5Å Yes Yes
3KPU_B (4092645) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
3KPU_A (4092645) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
3KPV_A (4253870) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes No
3KPV_B (4253870) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes No
3KPW_B (4254179) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
3KPW_A (4254179) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
3KPY_A (4155370) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
3KPY_B (4155370) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
3KQM_B (4080166) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
3KQM_A (4080166) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
3KQO_B (4062857) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
3KQO_A (4062857) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes Yes
3KQP_A (4139279) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes No
3KQP_B (4139279) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes No
3KQQ_A (4231409) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.5Å Yes Yes
3KQQ_B (4231409) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.5Å Yes Yes
3KQS_A (4073558) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2Å Yes No
3KQS_B (4073558) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2Å Yes No
3KQT_B (4047860) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes No
3KQT_A (4047860) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.4Å Yes No
3KQV_B (4044395) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.3Å Yes Yes
3KQV_A (4044395) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.3Å Yes Yes
3KQW_B (4264348) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.49Å Yes Yes
3KQW_A (4264348) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.49Å Yes Yes
3KQY_A (4028742) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.2Å Yes Yes
3KQY_B (4028742) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.2Å Yes Yes
3KR0_B (4159320) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.6Å Yes Yes
3KR0_A (4159320) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.6Å Yes Yes
3KR1_A (4145534) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.3Å Yes Yes
3KR1_B (4145534) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.3Å Yes Yes
3KR2_B (4256610) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.3Å Yes Yes
3KR2_A (4256610) Phenylethanolamine N-methyltransferase S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, Arylamine N-methyltransferase (Homo Multimer) 2.3Å Yes Yes
Ligand-based Druggability Score: 1.15
Ligand-based Druggability Score Percentile: 92%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PNMT is involved in 2 interactions in the network.


Druggability
Overall Druggability Percentile: 47.22
Druggability for Cancer Therapeutics: 47.77
Druggability for Other Therapeutics: 45.68
Cancer-Associated
Cancer-associated percentile : 39.35
Network Articulation Point
Is PNMT critical for communication in the network?


Detailed Graph Legend:Help