Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PNMT (P11086) - Overview - Molecular Target Synopsis

Protein


PNMT, Phenylethanolamine N-methyltransferase
Enzyme Classification 2.1.1.28
UniProt P11086

Also Known as PNMT_HUMAN, PNMT, PENT

Converts noradrenaline to adrenaline.

4MQ4
CRYSTAL STRUCTURE OF HPNMT IN COMPLEX WITH BISUBSTRATE INHIBITOR N-(3- ((((2S,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4- DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL)THIO)PROPYL)-1,2,3,4- TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for PNMT

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: PNMT is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PNMT has gain in 33 cell-lines, loss in 3 cell-lines and no signal in 969 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, MCF7, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DU4475, UACC-812, NCI-H2170

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For PNMT there are:
41 structures (82 chains) solved
41 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

PNMT is solved in complex with the approved drug(s):

RCO/RESORCINOL (4DM3_A, 4DM3_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PNMT has been screened with 266 compounds (444 bioactivities), 53 compounds have bioactivities that show binding affinity of <= 500nM (112 bioactivities). (see details)