Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Act5C (P10987) - Overview - Molecular Target Synopsis

Protein


Act5C, Actin-5C
UniProt P10987

Also Known as ACT1_DROME, Act5C

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction. Interacts with Rab6.

5WFN
REVISED MODEL OF LEIOMODIN 2-MEDIATED ACTIN REGULATION (ALTERNATE REFINEMENT OF PDB 4RWT)
RCSB/PDB
Inspect Structure
See all 3D Structures for Act5C

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: Act5C is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: Act5C is active in the following subcellular-locations: actin filament, brahma complex, cytoplasm, Ino80 complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Act5C has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Act5C there are:
13 structures (22 chains) solved
13 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Act5C has been screened with compounds ( bioactivities). (see details)