Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAPT (P10636) - Overview - Molecular Target Synopsis

Protein


MAPT, Microtubule-associated protein tau
UniProt P10636

Also Known as TAU_HUMAN, MAPT, MAPTL, MTBT1, TAU

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with SQSTM1 when polyubiquitinated (PubMed:15953362). Interacts with FKBP4 (By similarity). Binds to CSNK1D (PubMed:14761950). Interacts with SGK1 (PubMed:16982696). Interacts with EPM2A; the interaction dephosphorylates MAPT at Ser-396 (PubMed:19542233).

6HRE deposition date (2018-09-26)
PAIRED HELICAL FILAMENT FROM SPORADIC ALZHEIMER'S DISEASE BRAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for MAPT

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MAPT is active in the following subcellular-locations: axon, cell membrane, cell projection, cytoplasm, cytoskeleton, cytosol.
GO terms: MAPT is active in the following subcellular-locations: axolemma, axon, axon cytoplasm, cell body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, dendrite, growth cone, microtubule, microtubule associated complex, microtubule cytoskeleton, neurofibrillary tangle, neuronal cell body, nuclear periphery, nuclear speck, nucleus, plasma membrane, somatodendritic compartment, tubulin complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAPT has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, HCT_116, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, TC-71, MHH-ES-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


MAPT was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For MAPT there are:
49 structures (121 chains) solved
14 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MAPT has been screened with 200 compounds (294 bioactivities), 72 compounds have bioactivities that show binding affinity of <= 500nM (75 bioactivities). (see details)