Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

hsdR (P10486) - Overview - Molecular Target Synopsis

Protein


hsdR, Type I restriction enzyme EcoR124II R protein
Enzyme Classification 3.1.21.3
UniProt P10486

Also Known as T1R1_ECOLX, hsdR, hsr

The EcoR124/3 I enzyme recognizes 5'-GAAN(7)RTCG-3'. Subunit R is required for both nuclease and ATPase activities, but not for modification. The type I restriction/modification system is composed of three polypeptides R, M and S.

6H2J
CRYSTAL STRUCTURE OF THE HSDR SUBUNIT OF THE ECOR124I RESTRICTION ENZYME WITH THE C-TERMINAL DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for hsdR

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1033P10486-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project hsdR has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


hsdR was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For hsdR there are:
7 structures (16 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis