Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RRAS (P10301) - Overview - Molecular Target Synopsis

Protein


RRAS, Ras-related protein R-Ras
UniProt P10301

Also Known as RRAS_HUMAN, RRAS

Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267). Interacts with PLCE1 (PubMed:16537651). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts with OSBPL3 (PubMed:18270267).

2FN4
THE CRYSTAL STRUCTURE OF HUMAN RAS-RELATED PROTEIN, RRAS, IN THE GDP- BOUND STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for RRAS

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
218ENSG00000126458ENST00000246792ENSP00000246792P10301-1

Sub-cellular localization


UniProt: RRAS is active in the following subcellular-locations: cell membrane.
GO terms: RRAS is active in the following subcellular-locations: extracellular exosome, focal adhesion, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RRAS has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_92, EKVX, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CAL-120, HCC364, LOX-IMVI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, IMR-90, SK-N-SH

(see details)

3D Structures


For RRAS there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RRAS has been screened with compounds ( bioactivities). (see details)