Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAP2A (P10114) - Overview - Molecular Target Synopsis

Protein


RAP2A, Ras-related protein Rap-2a
UniProt P10114

Also Known as RAP2A_HUMAN, RAP2A

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. Interacts (GTP-bound form) with RUNDC3A. Interacts with RGS14; the interaction is GTP-dependent (By similarity). Interacts with PLCE1. Interacts with ARHGAP29, SGSM1, SGSM2 and SGSM3. Interacts (GTP-bound form preferentially) with TNIK (via the CNH domain); the interaction is direct and recruits RAP2A to the E3 ubiquitin ligase NEDD4. Interacts with MINK1. Interacts (GTP-bound form preferentially) with MAP4K4. Interacts with cytoskeletal actin.

3RAP
THE SMALL G PROTEIN RAP2 IN A NON CATALYTIC COMPLEX WITH GTP
RCSB/PDB
Inspect Structure
See all 3D Structures for RAP2A

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
183ENSG00000125249ENST00000245304ENSP00000245304P10114-1
108ENSG00000125249ENST00000476869ENSP00000436462

Sub-cellular localization


UniProt: RAP2A is active in the following subcellular-locations: midbody, recycling endosome membrane.
GO terms: RAP2A is active in the following subcellular-locations: cytosol, midbody, plasma membrane, recycling endosome, recycling endosome membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAP2A has gain in 4 cell-lines, loss in 9 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, IGROV1, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KARPAS-1106P, COLO 206F, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


For RAP2A there are:
3 structures (4 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAP2A has been screened with compounds ( bioactivities). (see details)