Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CALM3 (P0DP25) - Overview - Molecular Target Synopsis

Protein


CALM3, Calmodulin-3
UniProt P0DP25

Also Known as CALM3_HUMAN, CALM3, CALML2, CAM3, CAMC, CAMIII

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Interacts with MYO1C, MYO5A and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY (PubMed:9804419, PubMed:12871148, PubMed:15746192, PubMed:16760425, PubMed:17719545). Interacts with USP6; the interaction is calcium dependent (PubMed:16127172). Interacts with CDK5RAP2 (PubMed:20466722). Interacts with SCN5A (By similarity). Interacts with RYR1 (PubMed:18650434). Interacts with FCHO1 (PubMed:22484487). Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (By similarity). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with IQCF1 (By similarity). Interacts with SYT7 (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity). Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:27516456, PubMed:18650434). Interacts with PCP4; regulates calmodulin calcium-binding (PubMed:27876793). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates to the proper assembly of a functional heterotetrameric M channel (PubMed:27564677).

5DBR
CA2+ CAM WITH HUMAN CARDIAC NA+ CHANNEL (NAV1.5) INACTIVATION GATE
RCSB/PDB
Inspect Structure
See all 3D Structures for CALM3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: CALM3 is active in the following subcellular-locations: centrosome, cytoplasm, cytoskeleton, microtubule organizing center, spindle, spindle pole.
GO terms: CALM3 is active in the following subcellular-locations: calcium channel complex, catalytic complex, centrosome, cytoplasm, growth cone, mitochondrial membrane, myelin sheath, nucleus, plasma membrane, protein-containing complex, sarcomere, spindle microtubule, spindle pole, synaptic vesicle membrane, vesicle, voltage-gated potassium channel complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CALM3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_19, A549, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC12, NCI-H1155, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, SK-N-SH

(see details)

3D Structures


For CALM3 there are:
168 structures (292 chains) solved
13 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

CALM3 is solved in complex with the approved drug(s):

TFP/TRIFLUOPERAZINE (1CTR_A),
4DY/CAPSAICIN (2N27_A),
657/RILUZOLE (5V02_R).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CALM3 has been screened with 53 compounds (282 bioactivities), 6 compounds have bioactivities that show binding affinity of <= 500nM (30 bioactivities). (see details)