Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

slo (P0DF97) - Overview - Molecular Target Synopsis

Protein


slo, Streptolysin O
UniProt P0DF97

Also Known as TACY_STRPQ, slo

Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. Homooligomeric pore complex; when inserted in the host membrane.

4HSC
CRYSTAL STRUCTURE OF A CHOLESTEROL DEPENDENT CYTOLYSIN
RCSB/PDB
Inspect Structure
See all 3D Structures for slo

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
571P0DF97-1, P0DF96-1, P0C0I3-1

Sub-cellular localization


UniProt: slo is active in the following subcellular-locations: host cell membrane, secreted.
GO terms: slo is active in the following subcellular-locations: extracellular region, host cell plasma membrane, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project slo has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For slo there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


slo has been screened with compounds ( bioactivities). (see details)