Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HBA1 (P0CH25) - Overview - Molecular Target Synopsis

Protein


HBA1, Hemoglobin subunit alpha-1
UniProt P0CH25

Also Known as HBA1_CAPHI, HBA1

Involved in oxygen transport from the lung to the various peripheral tissues. Heterotetramer of two alpha chains and two beta chains.

3EU1
CRYSTAL STRUCTURE DETERMINATION OF GOAT HEMOGLOBIN (CAPRA HIRCUS) AT 3 ANGSTROM RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for HBA1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: HBA1 is active in the following subcellular-locations: hemoglobin complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HBA1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For HBA1 there are:
3 structures (8 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HBA1 has been screened with compounds ( bioactivities). (see details)