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UBB (P0CG53) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 11/06/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 11/06/2019)


Chains assessed4
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria4


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4BBN_C Polyubiquitin-B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.68 66.2 17 No No
2 empty 1.7 62.2 20.7 No No
3 empty 2.69 61.7 12.6 No No
4 empty 2.81 58.2 15.2 No No
5 empty 2.4 69.1 6.2 No No
6 empty 1.45 60.1 8.7 No No
7 empty 2.43 55.4 7.6 No No
8 empty 2.28 73.1 0 No No
9 empty 1.93 63.5 4.8 No No
10 empty 1.67 100 0 Yes No
5TR4_B Polyubiquitin-B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.46 59.2 26.5 Yes No
2 empty 2.33 44.2 14 No No
3 empty 2.45 61.5 13.2 No No
4 empty 2.85 51.2 10 No No
5 empty 2.95 64 8.4 No No
6 empty 2.33 70.6 7.4 No No
7 empty 2.71 70.2 6.9 No No
8 empty 2.17 59.4 4.8 No No
9 empty 2.17 71.2 6.4 No No
10 empty 2.98 58.6 5.9 No No
4BBN_F Polyubiquitin-B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 57.6 24.9 Yes No
2 empty 2.79 69.3 13.1 No No
3 empty 2.61 66.8 11.1 No No
4 empty 3.44 47.8 7.3 No No
5 empty 2 67.5 5.1 No No
6 empty 2.61 68.8 5.3 No No
7 empty 3.38 67.8 6.6 No No
8 empty 2.05 77.6 5.4 No No
9 empty 2.03 61.2 5.5 No No
10 empty 3.66 53.3 5 No No
5TR4_D Polyubiquitin-B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.53 60.4 25.4 Yes No
2 empty 2.28 46 14.6 No No
3 empty 2.51 60.2 14.4 No No
4 empty 2.03 69.7 6.6 No No
5 empty 2.98 75.5 7.1 No No
6 empty 2.18 64.6 6.8 No No
7 empty 3 63.1 5.1 No No
8 empty 2.3 56.5 6.4 No No
9 empty 1.32 67.2 4.8 No No
10 empty 2.69 62.8 5.8 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed31
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria4

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1P3Q_U (87750) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 1.7Å Yes No
1P3Q_V (87751) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 1.7Å No No
1UZX_B (100239) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 1.85Å No No
1WR6_E (121186) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.6Å No No
1WR6_F (121187) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.6Å No No
1WR6_G (121188) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.6Å No No
1WR6_H (121189) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.6Å No No
1WRD_B (121194) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 1.75Å No No
1YD8_V (122975) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.8Å No No
1YD8_U (122974) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.8Å Yes No
2C7M_B (130068) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.4Å No No
2C7N_F (130073) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.1Å No No
2C7N_H (130075) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.1Å Yes No
2C7N_J (130077) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.1Å No No
2C7N_B (130070) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.1Å No No
2C7N_D (130072) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.1Å No No
2C7N_L (130078) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.1Å No No
2D3G_A (131206) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 1.7Å No No
2D3G_B (131207) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 1.7Å No No
2DX5_B (131867) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 3.35Å No No
2FID_A (133516) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.8Å No No
2FIF_E (133522) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.49Å No No
2FIF_C (133520) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.49Å No No
2FIF_A (133518) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 2.49Å No No
2HD5_B (136341) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 1.85Å No No
2OOB_B (139167) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 1.9Å No No
2QHO_E (150792) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 1.85Å No No
2QHO_G (150793) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 1.85Å No No
2QHO_C (150791) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 1.85Å Yes No
2QHO_A (150790) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, Ubiquitin-related 1.85Å No No
2XBB_C (3580453) Polyubiquitin-B beta-Grasp (ubiquitin-like), Ubiquitin-like, UNMATCHED 2.68Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score