Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Gene Expression
Gene Copy Number Variation
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UBB (P0CG53) - Overview - Molecular Target Synopsis

Protein


UBB, Polyubiquitin-B
UniProt P0CG53

Also Known as UBB_BOVIN, UBB

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

5TR4
STRUCTURE OF UBIQUITIN ACTIVATING ENZYME (UBA1) IN COMPLEX WITH UBIQUITIN AND TAK-243
RCSB/PDB
Inspect Structure
See all 3D Structures for UBB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
305P0CG53-1

Sub-cellular localization


UniProt: UBB is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: UBB is active in the following subcellular-locations: cytoplasm, mitochondrion, neuron projection, neuronal cell body, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project UBB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For UBB there are:
3 structures (5 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis