Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
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UBC (P0CG48) - Overview - Molecular Target Synopsis

Protein


UBC, Polyubiquitin-C
UniProt P0CG48

Also Known as UBC_HUMAN, UBC

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

6N6R
CRYSTAL STRUCTURE OF ABIN-1 UBAN IN COMPLEX WITH TWO M1-LINKED DI- UBIQUITINS
RCSB/PDB
Inspect Structure
See all 3D Structures for UBC

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: UBC is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: UBC is active in the following subcellular-locations: cytoplasm, cytosol, endocytic vesicle membrane, endoplasmic reticulum membrane, endosome membrane, extracellular exosome, extracellular space, host cell, mitochondrial outer membrane, nucleoplasm, nucleus, plasma membrane, vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project UBC has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, MCF7, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MKN-74, NCI-H2052, LCLC-103H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, IMR-90, BJ

(see details)

3D Structures


For UBC there are:
248 structures (511 chains) solved
19 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

UBC is solved in complex with the approved drug(s):

CCS/CARBOCYSTEINE (3RUL_A, 3RUL_B, 3RUL_C, 3RUL_D, 3VFK_A).

(see details)
Molecular Target 3D Synopsis