Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTT2B (P0CG30) - Overview - Molecular Target Synopsis

Protein


GSTT2B, Glutathione S-transferase theta-2B
Enzyme Classification 2.5.1.18
UniProt P0CG30

Also Known as GSTT2_HUMAN, GSTT2B, GSTT2

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity. Homodimer.

4MPG
CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE TRANSFERASE THETA-2, COMPLEX WITH GLUTATHIONE AND UNKNOWN LIGAND, TARGET EFI-507257
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTT2B

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
244ENSG00000133433ENST00000290765ENSP00000290765P0CG30-1
230ENSG00000133433ENST00000404172ENSP00000385116

Sub-cellular localization


UniProt: GSTT2B is active in the following subcellular-locations: cytoplasm.
GO terms: GSTT2B is active in the following subcellular-locations: cytosol, extracellular exosome, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTT2B has gain in 5 cell-lines, loss in 3 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, NCI-H810, EKVX

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, IMR-90, HUVEC

(see details)

3D Structures


For GSTT2B there are:
4 structures (8 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTT2B has been screened with compounds ( bioactivities). (see details)