Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTT2 (P0CG29) - Overview - Molecular Target Synopsis

Protein


GSTT2, Glutathione S-transferase theta-2
Enzyme Classification 2.5.1.18
UniProt P0CG29

Also Known as GST2_HUMAN, GSTT2

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity. Homodimer.

4MPF
CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE TRANSFERASE THETA-2, COMPLEX WITH INORGANIC PHOSPHATE, GSH FREE, TARGET EFI-507257
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTT2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
244ENSG00000099984ENST00000215780ENSP00000215780P0CG29-1

Sub-cellular localization


UniProt: GSTT2 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTT2 is active in the following subcellular-locations: cytoplasm, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTT2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: EKVX, T47D, MDA_N

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 454, Hs 746T, NCI-H1581

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For GSTT2 there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTT2 has been screened with 2 compounds (2 bioactivities). (see details)